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公开(公告)号：EP2874663B1
公开(公告)日：2018-01-10
申请号：EP13773359.8
申请日：2013-07-19
发明人： GRANUCCI, Francesca , PROSPERI, Davide , ZANONI, Ivan , CORSI, Fabio, Ruggero, Maria , COLOMBO, Miriam
CPC分类号： A61K9/5138 , A61K9/5115 , A61K38/1709 , A61K47/6935 , A61K49/1851 , C07K14/47
摘要： The present invention relates to methods and means of transport of active substances in the cell cytosol. In particular, the invention relates to means that make it possible to transport directly in the cytosol substances capable of interacting with protein systems, such as the family of nuclear factors of activated T-cells (NFATs) or nucleic acids localized in the cytosol. In particular, the invention relates to nanoconstructs useful in the treatment of inflammatory diseases, methods for their preparation, and compositions containing them.
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公开(公告)号：EP2874663A1
公开(公告)日：2015-05-27
申请号：EP13773359.8
申请日：2013-07-19
发明人： GRANUCCI, Francesca , PROSPERI, Davide , ZANONI, Ivan , CORSI, Fabio, Ruggero, Maria , COLOMBO, Miriam
CPC分类号： A61K9/5138 , A61K9/5115 , A61K38/1709 , A61K47/6935 , A61K49/1851 , C07K14/47
摘要： The present invention relates to methods and means of transport of active substances in the cell cytosol. In particular, the invention relates to means that make it possible to transport directly in the cytosol substances capable of interacting with protein systems, such as the family of nuclear factors of activated T-cells (NFATs) or nucleic acids localized in the cytosol. In particular, the invention relates to nanoconstructs useful in the treatment of inflammatory diseases, methods for their preparation, and compositions containing them.
摘要翻译： 本发明涉及活性物质在细胞质溶胶中的运输方法和方法。 特别地，本发明涉及使得可以直接在能够与蛋白质系统相互作用的细胞质物质例如活化的T细胞（NFAT）的核因子家族或定位于胞质溶胶中的核酸的物质转运。 特别地，本发明涉及可用于治疗炎性疾病的纳米结构，其制备方法和含有它们的组合物。
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