公开(公告)号：EP3682039A1

公开(公告)日：2020-07-22

申请号：EP18769361.9

申请日：2018-09-13

申请人： Université Claude Bernard Lyon 1 ,  Centre National de la Recherche Scientifique ,  Institut National des Sciences Appliquées de Lyon ,  CPE Lyon Formation Continue et Recherche ,  Ecole Nationale Supérieure de Chimie de Montpellier ,  Université de Montpellier

发明人： LECLAIRE, Julien ,  SEPTAVAUX, Jean ,  METRO, Thomas-Xavier

IPC分类号： C22B1/00 ,  C22B3/16 ,  C22B59/00 ,  C22B60/00

公开(公告)号：EP3527580A1

公开(公告)日：2019-08-21

申请号：EP18305160.6

申请日：2018-02-16

申请人： Centre National de la Recherche Scientifique CNRS ,  Universite De Montpellier (Universite Montpellier 2 Sciences Et Techniques) ,  Ecole Nationale Supérieure de Chimie de Montpellier ,  Ecole des Mines d'Ales ,  Association pour la Recherche et le Développement des Méthodes et Processus Industriels (ARMINES)

发明人： YEBOUE, Yves ,  GALLARD, Benjamin ,  LE MOIGNE, Nicolas ,  LAMATY, Frédéric ,  MARTINEZ, Jean ,  METRO, Thomas-Xavier

IPC分类号： C07K1/06 ,  B29C47/38

摘要： The present disclosure relates to A a continuous, solvent-free and non-enzymatic method for synthesizing a compound of formula (I) :

         Ra-POLYPEP-Rc     (I)

wherein :
POLYPEP is a poly-amino acid compound,
Ra and Rc are as specified in the disclosure,
which method comprises the steps of:
a) feeding an extrusion reactor with
(1) a compound of formula (II)

         Ra-PEPNt-Rg     (II)

wherein;
PEPNt is a mono- or a poly-aminoacid compound,
Ra and Rg are as specified in the disclosure,
and
(2) a compound of formula (III)

         H-PEPCt-Rc     (III)

wherein :
PEPCt is a mono- or a poly-amino acid compound, and
Rc is as defined in the disclosure
in the absence of any solvent,
so that the compound of formula (II) and the compound of formula (III) react together for generating a compound of formula (I), and

b) collecting the compound of formula (I) from the extrusion reactor.