公开(公告)号：EP3003414B1

公开(公告)日：2019-10-16

申请号：EP14731810.9

申请日：2014-06-03

申请人： Université Clermont Auvergne ,  Centre National de la Recherche Scientifique (C.N.R.S.)

发明人： LAO, Jonathan Claude Alexandre ,  LACROIX, Joséphine ,  JALLOT, Edouard Daniel Albert ,  DIEUDONNE, Xavier

IPC分类号： A61L27/58 ,  A61L27/54 ,  A61L27/24 ,  A61L27/22 ,  A61L27/10 ,  A61L27/56 ,  A61L27/30 ,  A61L27/18 ,  A61L27/16 ,  A61L27/20 ,  A61L27/44

公开(公告)号：EP3003415B1

公开(公告)日：2018-05-16

申请号：EP14731811.7

申请日：2014-06-03

申请人： Université Clermont Auvergne ,  Centre National de la Recherche Scientifique

发明人： LAO, Jonathan, Claude, Alexandre ,  LACROIX, Joséphine ,  JALLOT, Edouard, Daniel, Albert ,  DIEUDONNE, Xavier

IPC分类号： A61L27/10 ,  A61L27/22 ,  A61L27/24 ,  A61L27/54 ,  A61L27/16 ,  A61L27/20 ,  A61L27/30 ,  A61L27/18 ,  A61L27/44 ,  A61L27/56 ,  A61L27/58

CPC分类号： A61L27/10 ,  A61L27/16 ,  A61L27/18 ,  A61L27/20 ,  A61L27/222 ,  A61L27/24 ,  A61L27/306 ,  A61L27/446 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L2300/102 ,  A61L2300/412 ,  A61L2420/02 ,  A61L2430/02 ,  C08L5/08 ,  C08L5/02 ,  C08L5/04 ,  C08L29/04 ,  C08L71/02 ,  C08L89/00

公开(公告)号：EP3003414A1

公开(公告)日：2016-04-13

申请号：EP14731810.9

申请日：2014-06-03

申请人： Université Blaise Pascal - Clermont-Ferrand II ,  Centre National de la Recherche Scientifique (CNRS)

发明人： LAO, Jonathan, Claude, Alexandre ,  LACROIX, Joséphine ,  JALLOT, Edouard, Daniel, Albert ,  DIEUDONNE, Xavier

IPC分类号： A61L27/16 ,  A61L27/18 ,  A61L27/20 ,  A61L27/30 ,  A61L27/44 ,  A61L27/56

摘要： The invention relates to an implant material for filling bone defects, for bone regeneration and for bone tissue engineering, to an implant comprising this material, to a method for producing such an implant, and to a method for producing a hybrid material. The implant material of the invention comprises a hybrid material comprising: a bioactive glass M based on SiO
2 and CaO, optionally containing P
2 O
5 and/or optionally doped with strontium, and a biodegradable polymer P soluble in a solvent and chosen from among the bioresorbable polysaccharides, preferably chosen from among dextran, hyaluronic acid, agar, chitosan, alginic acid, sodium or potassium alginate, galactomannan, carrageenan, pectin; the bioresorbable polyesters, preferably polyvinyl alcohol, polylactic acid; or the biodegradable synthetic polymers, preferably a polyethylene glycol or polycaprolactone; and proteins, preferably gelatin or collagen, and it consists of a matrix comprising at least the biodegradable polymer P, this matrix having pores having the shape of spheres or polyhedrons inscribed within a sphere, the diameter of the spheres being between 100 and 900 μm inclusive, with a deviation between the diameter of the smallest sphere and the largest being at most 70% with respect to the arithmetic mean diameter of all the spheres of the implant, and the interconnections between the pores having their smallest dimension at between 25 μm and 250 μm inclusive, at least 70% by number of pores having at least one interconnection with another pore. The invention has an application in the medical field in particular.

公开(公告)号：EP3003415A1

公开(公告)日：2016-04-13

申请号：EP14731811.7

申请日：2014-06-03

申请人： Université Blaise Pascal Clermont II ,  Centre National de la Recherche Scientifique (CNRS)

发明人： LAO, Jonathan, Claude, Alexandre ,  LACROIX, Joséphine ,  JALLOT, Edouard, Daniel, Albert ,  DIEUDONNE, Xavier

IPC分类号： A61L27/16 ,  A61L27/18 ,  A61L27/20 ,  A61L27/30 ,  A61L27/44 ,  A61L27/56

CPC分类号： A61L27/10 ,  A61L27/16 ,  A61L27/18 ,  A61L27/20 ,  A61L27/222 ,  A61L27/24 ,  A61L27/306 ,  A61L27/446 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L2300/102 ,  A61L2300/412 ,  A61L2420/02 ,  A61L2430/02 ,  C08L5/08 ,  C08L5/02 ,  C08L5/04 ,  C08L29/04 ,  C08L71/02 ,  C08L89/00

摘要： The invention relates to an implant material for filling bone defects, for bone regeneration and for bone tissue engineering, to an implant comprising this material, and to a method for producing such an implant. The implant material of the invention comprises: a bioactive glass M based on SiO
2 and CaO, optionally containing P
2 O
5 and/or optionally doped with strontium, and a biodegradable polymer P soluble in at least one solvent S1 and chosen from among the bioresorbable polysaccharides, preferably chosen from among dextran, hyaluronic acid, agar, chitosan, alginic acid, sodium or potassium alginate, galactomannan, carrageenan, pectin; the bioresorbable polyesters, preferably polyvinyl alcohol or polylactic acid; the biodegradable synthetic polymers, preferably a polyethylene glycol or polycaprolactone; and proteins, preferably gelatin or collagen, and it consists of a matrix comprising at least the biodegradable polymer P, this matrix being covered by the bioactive glass M or by a hybrid material H formed by a biodegradable polymer identical to or different from the biodegradable polymer P and the bioactive glass M, this matrix having at least 70% by number of pores having at least one interconnection with another pore, and the shape of spheres or polyhedrons inscribed within a sphere, the diameter of the spheres being between 100 and 900 μm inclusive, with a deviation between the diameter of the smallest sphere and the largest being at most 70% with respect to the arithmetic mean diameter of all the spheres of the implant, and the interconnections between the pores having their smallest dimension between 25 μm and 250 μm inclusive. The invention has an application in the medical field in particular.