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公开(公告)号:EP3277804A1
公开(公告)日:2018-02-07
申请号:EP16714380.9
申请日:2016-03-31
申请人: Université Pierre et Marie Curie - Paris 6 (UPMC) , Institut National de la Santé et de la Recherche Médicale , Agencia Estalal Consejo Superior de Investigaciones Cientificas , Katholieke Universiteit Leuven
发明人: REBOLLO GARCIA, Angelita , BRAVO SICILIA, Jeronimo , FOMINAYA GUTIERREZ, Jesus Maria , WAELKENS, Etienne , JANSSENS, Veerle
IPC分类号: C12N9/16
CPC分类号: C12N9/16 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/4702 , C07K2319/01 , C07K2319/10 , C07K2319/70 , C12Y301/03016
摘要: The invention provide chimeric peptides comprising a chimeric peptide comprising a cell-penetrating peptide linked to a pro-apoptotic peptide, wherein the pro-apoptotic peptide is derived from, or consists of, a portion of PP2A protein that binds a SET protein or is derived from, or consists of, a portion of the SET protein that binds PP2A protein.