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    CHITOSAN BIOMIMETIC SCAFFOLDS AND METHODS FOR PREPARING THE SAME
    3.
    发明公开
    CHITOSAN BIOMIMETIC SCAFFOLDS AND METHODS FOR PREPARING THE SAME 有权
    维多利亚州自然保护联盟

    公开(公告)号：EP2575905A1

    公开(公告)日：2013-04-10

    申请号：EP11721057.5

    申请日：2011-05-24

    申请人： Université de Liège

    发明人： FILEE, Patrice ,  FREICHELS, Astrid ,  JEROME, Christine ,  AQIL, Abdelhafid ,  COLIGE, Alain ,  TCHEMTCHOUA TATEU, Victor

    IPC分类号： A61L15/28 ,  A61L15/42

    CPC分类号： A61F13/00008 ,  A61F13/00012 ,  A61F13/00063 ,  A61L15/28 ,  A61L15/425 ,  A61L15/64 ,  A61L27/20 ,  A61L27/48 ,  A61L27/56 ,  A61L27/58 ,  A61L27/60 ,  A61L2400/12 ,  C08L5/08

    摘要： The invention concerns chitosan-based biomimetic scaffolds and methods for modulating their intrinsic properties such as rigidity, elasticity, resistance to mechanical stress, porosity, biodegradation and absorbance of exudates. Therefore, the present invention relates to a layered chitosan-based scaffold wherein said layered scaffold comprises at least two fused layers, wherein at least one layer consists of a chitosan nanofiber scaffold membrane and at least one of the other layers of a porous chitosan scaffold support layer. Moreover, the present invention provides a layered chitosan-based scaffold characterized by (i) a good adhesion between the porous and nanofiber layers, (ii) a tuneable porosity of the nanofiber layer by tuning the distance between the nanofibers, (iii) a stable nanofibers and porous morphology even when immersed in water or other solvents and a process for the preparation of such layered chitosan-based scaffold.Finally, the present invention provides the use of the layered electrospun chitosan-based scaffold of the invention or the layered electrospun chitosan-based scaffold produced by the process of the invention as a wound dressing, in tissue engineering or for biomedical applications.

    摘要翻译： 本发明涉及基于壳聚糖的仿生支架和用于调节其固有性质的方法，例如刚性，弹性，抗机械应力，孔隙率，生物降解和渗出物的吸光度。 因此，本发明涉及层状壳聚糖类支架，其中所述层状支架包括至少两个熔融层，其中至少一层由壳聚糖纳米纤维支架膜和多孔壳聚糖支架支架的至少一层 层。 此外，本发明提供了一种基于层状壳聚糖的支架，其特征在于：（i）多孔和纳米纤维层之间良好的粘附性，（ii）通过调节纳米纤维之间的距离来调节纳米纤维层的可调孔隙率，（iii）稳定的 纳米纤维和多孔形态，即使浸入水或其他溶剂中，以及制备这种层状壳聚糖类支架的方法。最后，本发明提供了本发明的层状静电纺丝壳聚糖基支架或层状电纺壳聚糖 基于本发明的方法生产的作为伤口敷料，组织工程或生物医学应用的支架。