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公开(公告)号:EP4448553A1
公开(公告)日:2024-10-23
申请号:EP22839741.0
申请日:2022-12-16
申请人: Université de Lille , Centre National de la Recherche Scientifique (CNRS) , Université d'Aix Marseille , SORBONNE UNIVERSITE , Ecole Centrale de Marseille
发明人: TASIEMSKI, Aurélie , WICHLACZ, Céline , MARESCA, Marc , CANAAN, Stéphane , CAVALIER, Jean-François , MABROUK, Kamel , HOURDEZ, Stéphane
IPC分类号: C07K14/435 , A61K38/00 , A61P31/04
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公开(公告)号:EP4198045A1
公开(公告)日:2023-06-21
申请号:EP21306811.7
申请日:2021-12-16
申请人: Université de Lille , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , Université d'Aix Marseille , SORBONNE UNIVERSITE , Ecole Centrale de Marseille
发明人: TASIEMSKI, Aurélie , WICHLACZ, Céline , MARESCA, Marc , CANAAN, Stéphane , CAVALIER, Jean-François , MABROUK, Kamel , HOURDEZ, Stéphane
IPC分类号: C07K14/435 , A61K38/00 , A61P31/04
摘要: The present invention relates to antimicrobial peptides, variants and chemical analogues thereof; in particular, a peptide of 20 amino acids, named Michelicin, having the sequence RVCVRICRNGRCYRRCWNT, derived from a longer precursor with a BRICHOS domain from the marine worm Capitella. The peptide has several cysteines which form disulfide bridges and provide stability in salt conditions. Several derivatives and analogues were produced. The peptide and the derivatives show antimicrobial activity against a wide range of bacteria. The application also concerns nucleic acid sequences encoding these, pharmaceutical composition and to their use as a drug, preservative and disinfectant.
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公开(公告)号:EP2488216B1
公开(公告)日:2016-12-21
申请号:EP10763732.4
申请日:2010-10-15
申请人: Centre National de la Recherche Scientifique (C.N.R.S.) , Université de Lille 1 Sciences et Technologies
发明人: TASIEMSKI, Aurélie , SALZET, Michel
CPC分类号: A61K35/62 , A61L2202/25 , Y02A50/473 , Y02A50/481
摘要: The present invention relates to the use of extract of leeches' saliva as anti-bacterial agent for the manufacture of different compositions, such as a pharmaceutical composition, a cosmetic composition or a cleaning product.
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