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1.发明授权UTILISATION D'ANTICORPS MONOCLONAUX SPÉCIFIQUES DE LA FORME O-ACÉTYLÉE DU GANGLIOSIDE GD2 DANS LE TRAITEMENT DE CERTAINS CANCERS 有权GD2神经节苷脂特异性单克隆抗体的O-乙酰化形式对某些癌症的治疗中使用
公开(公告)号：EP2076542B1
公开(公告)日：2012-08-15
申请号：EP07821118.2
申请日：2007-10-10
申请人： Université de Nantes
发明人： BIRKLE, Stéphane , MUSSINI, Jean-Marie , AUBRY, Jacques , BARBET, Jacques , CHATAL, Jean-François , MEZAZIGH HAMI, Assia , SUPIOT, Stéphane
IPC分类号： C07K16/30 , C12N15/13 , C12N15/63 , C12P21/08 , G01N33/577 , G01N33/574 , A61K39/395 , A61K47/48 , A61P35/00
CPC分类号： C07K16/3084 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565
摘要： The invention relates to the use of monoclonal antibodies that only recognise the O-acetylated form of the GD2 ganglioside, or fragments of said antibody, for the diagnosis and the treatment of cancers in which the cells express the O-acetylated GD2, said antibody or said fragment recognising the O-acetylated GD2 molecules expressed by the tumoral cells and not recognising the GD2 molecules expressed at the surface of the peripheral nerves, in order to increase the specificity of the diagnosis and reduce the toxicity of the treatments. The invention also relates to artificially modified antibodies advantageously used for treating and diagnosing cancers in which the cells express the O-acetylated GD2.
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2.发明公开UTILISATION D'ANTICORPS MONOCLONAUX SPECIFIQUES DE LA FORME O-ACETYLEE DU GANGLIOSIDE GD2 DANS LE TRAITEMENT DE CERTAINS CANCERS 有权GD2神经节苷脂特异性单克隆抗体的O-乙酰化形式对某些癌症的治疗中使用
公开(公告)号：EP2076542A1
公开(公告)日：2009-07-08
申请号：EP07821118.2
申请日：2007-10-10
申请人： Université de Nantes
发明人： BIRKLE, Stéphane , MUSSINI, Jean-Marie , AUBRY, Jacques , BARBET, Jacques , CHATAL, Jean-François
IPC分类号： C07K16/30 , C12N15/13 , C12N15/63 , C12P21/08 , G01N33/577 , G01N33/574 , A61K39/395 , A61K47/48 , A61P35/00
CPC分类号： C07K16/3084 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565
摘要： The invention relates to the use of monoclonal antibodies that only recognise the O-acetylated form of the GD2 ganglioside, or fragments of said antibody, for the diagnosis and the treatment of cancers in which the cells express the O-acetylated GD2, said antibody or said fragment recognising the O-acetylated GD2 molecules expressed by the tumoral cells and not recognising the GD2 molecules expressed at the surface of the peripheral nerves, in order to increase the specificity of the diagnosis and reduce the toxicity of the treatments. The invention also relates to artificially modified antibodies advantageously used for treating and diagnosing cancers in which the cells express the O-acetylated GD2.
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