专利检索 ap:("Université de la Méditerranée" OR "Assistance Publique Hôpitaux de Marseille") AND inv:"FANCIULLINO, Raphaëlle" 第 1 页

1.

发明公开
LIPOSOMAL FORMULATIONS FOR TREATING CANCER 审中-公开
标题翻译：脂质体制剂用于治疗癌症的

公开(公告)号：EP2187868A1

公开(公告)日：2010-05-26

申请号：EP08804068.8

申请日：2008-09-11

申请人： Université de la Méditerranée , Assistance Publique Hôpitaux de Marseille

发明人： CICCOLINI, Joseph , FANCIULLINO, Raphaëlle

IPC分类号： A61K9/127 , A61K31/00

CPC分类号： A61K9/127 , A61K9/00 , A61K9/1277 , A61K9/1278 , A61K31/513 , A61K31/7076 , A61K45/06 , A61K2300/00

摘要： The invention provides a pharmaceutical composition comprising liposomes which coencapsulate 5-fluorouracil (5-FU) and 2′-deoxyinosine (d-Ino). In a preferred embodiment, the liposomes comprise phosphatidylcholine (PC), phosphatidyl-glycol (PG) and sterol, preferably in a molar ratio PC/PG/sterol of 20-80/10-60/15-60. The invention further provides a method for preparing liposomes which coencapsulate 5-fluorouracil (5-FU) and 2′-deoxyinosine (d-Ino), and the use thereof for the manufacture of a medicament for treating cancer in a patient.