公开(公告)号：EP2294422A2

公开(公告)日：2011-03-16

申请号：EP09740956.9

申请日：2009-06-08

申请人： Universita' Cattolica Del Sacro Cuore

发明人： CASTAGNOLA, Massimo ,  MESSANA, Irene ,  INZITARI, Rosanna ,  FANALI, Chiara ,  CABRAS, Tiziana ,  GURRIERI, Fiorella ,  TORRIOLI, Maria, Giulia ,  NERI, Giovanni

IPC分类号： G01N33/68

CPC分类号： G01N33/6896 ,  G01N2800/28

摘要： The invention relates to the determination of phosphorylation levels of some specific salivary peptides (statherin, histatin 1, acidic proline-rich proteins, both in whole form (PRP-1 type) and in truncated form (PRP-3 type) as a non-invasive diagnostic marker with a >40% sensitivity for defining autism spectrum disorders (ASDs) patients, methods for performing said determination, a kit for the non-invasive diagnosis of at least 40% of autism cases, containing means for such a determination, and the use of such a determination for therapeutical research on autism.

摘要翻译： 本发明涉及一些特异性唾液肽（statherin，组氨素1，富含酸性脯氨酸的蛋白质，全部形式（PRP-1型）和截短形式（PRP-3型））的磷酸化水平， 用于定义自闭症谱系障碍（ASD）患者> 40％敏感性的侵入性诊断标记，执行所述测定的方法，用于非侵入性诊断至少40％的自闭症病例的试剂盒，其包含用于测定的手段，以及 使用这种自闭症治疗研究的决定。