专利检索 ap:("Universita' degli studi di Bari" OR "Universita' Degli Studi di Chieti") AND inv:"DI NUNNO, Leonardo" 第 1 页

1.

发明公开
ISOXAZOLE DERIVATIVES AND THEIR USE AS CYCLOOXYGENASE INHIBITORS 有权
标题翻译：异恶唑衍生物及其作为环加氧酶抑制剂的用途

公开(公告)号：EP1706390A2

公开(公告)日：2006-10-04

申请号：EP05702217.0

申请日：2005-01-12

申请人： Universita' degli studi di Bari , Universita' Degli Studi di Chieti

发明人： SCILIMATI, Antonio , DI NUNNO, Leonardo , VITALE, Paola , PATRIGNANI, Paola , TACCONELLI, Stefania , PORRECA, Ettore , STUPPIA, Liborio

IPC分类号： C07D261/00

CPC分类号： C07D261/08 , C07D413/04

摘要： The present invention refers to isoxazole derivatives, in particular 3,4-diaryl isoxazole derivatives, to their pharmaceutical compositions, the process for preparing them and their use as inhibitors of cycloosygenase, in particular of cycloosygenase 1 and 2 (COX-1) (COX-2). The present invention also refers to a process for determining the potential toxicity of compounds that inhibit cycloosygenase (COX), in particular cycloosygenase-2 (COX-2) isoform, and to the use of compounds that inhibit cycloosygenase (COX), in particular cycloosygenase-2 (COX-2) and their pharmaceutical compositions, in subjects for whom the potential cardiovascular toxicity of said compounds is reduced.