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1.发明公开METHODS AND REAGENTS FOR EFFICIENT AND TARGETED DELIVERY OF THERAPEUTIC MOLECULES TO CXCR4 CELLS 有权方法和试剂细胞CXCR4治疗性分子在高效，靶向给药
公开(公告)号：EP2663336A1
公开(公告)日：2013-11-20
申请号：EP12704711.6
申请日：2012-01-13
申请人： Universitat Autònoma De Barcelona , Institut Recerca Hospital de la Santa Creu i Sant Pau , Centro Investigación Biomédica en Red (Ciber BBN)
发明人： VILLAVERDE CORRALES, Antonio , VÁZQUEZ GÓMEZ, Esther , CÉSPEDES NAVARRO, María Virtudes , CASANOVA RIGAT, Isolda , FERRER MIRALLES, Neus , MANGUES BAFALLUY, Ramon , UNZUETA ELORZA, Ugutz
IPC分类号： A61K47/48 , C07K14/435 , C12N15/62
摘要： The invention relates to conjugates comprising a targeting moiety specific for the CXCR4 based on the polyphemusin-derived peptide and a therapeutic or imaging agent. The invention relates as well to the application of said conjugates for the therapy and diagnostics which require the specific targeting to CXCR4+ cells.
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2.发明授权METHODS AND REAGENTS FOR EFFICIENT AND TARGETED DELIVERY OF THERAPEUTIC MOLECULES TO CXCR4 CELLS 有权有效和有针对性地将治疗性分子递送至CXCR4细胞的方法和试剂
公开(公告)号：EP2663336B1
公开(公告)日：2017-08-09
申请号：EP12704711.6
申请日：2012-01-13
申请人： Universitat Autònoma de Barcelona , Fundacio Institut de Recerca de l'Hospital de la Santa Creu i sant Pau , Centro de Investigación Biomédica en Red
发明人： VILLAVERDE CORRALES, Antonio , VÁZQUEZ GÓMEZ, Esther , CÉSPEDES NAVARRO, María Virtudes , CASANOVA RIGAT, Isolda , FERRER MIRALLES, Neus , MANGUES BAFALLUY, Ramon , UNZUETA ELORZA, Ugutz
IPC分类号： A61K47/50 , C07K14/435 , C12N15/62
摘要： The invention relates to conjugates comprising a targeting moiety specific for the CXCR4 based on the polyphemusin-derived peptide and a therapeutic or imaging agent. The invention relates as well to the application of said conjugates for the therapy and diagnostics which require the specific targeting to CXCR4+ cells.
摘要翻译： 本发明涉及包含基于聚肌球蛋白衍生肽的CXCR4特异性靶向部分和治疗剂或成像剂的缀合物。 本发明还涉及所述缀合物用于需要对CXCR4 +细胞进行特异性靶向的治疗和诊断的应用。
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