公开(公告)号：EP3287437B1

公开(公告)日：2019-12-11

申请号：EP17191078.9

申请日：2012-10-08

申请人： Universitat de les Illes Balears

发明人： ESCRIBÁ RUIZ, Pablo Vicente ,  MARTÍN, María Laura ,  NOGUERA SALVÀ, María Antònia ,  BUSQUETS XAUBET, Xavier ,  LÓPEZ JIMÉNEZ, David ,  IBARGUREN AIZPITARTE, Maitane ,  SOTO SALVADOR, José Javier ,  YUS ASTIZ, Miguel

IPC分类号： C07C59/42 ,  C07C51/493 ,  A61K31/201 ,  A61P35/00 ,  A61P9/00

公开(公告)号：EP2774910B1

公开(公告)日：2017-09-27

申请号：EP12838506.9

申请日：2012-10-08

申请人： Universitat de les Illes Balears

发明人： ESCRIBÁ RUIZ, Pablo Vicente ,  MARTÍN, María Laura ,  NOGUERA SALVÀ, María Antònia ,  BUSQUETS XAUBET, Xavier ,  LÓPEZ JIMÉNEZ, David ,  IBARGUREN AIZPITARTE, Maitane ,  SOTO SALVADOR, José Javier ,  YUS ASTIZ, Miguel

IPC分类号： C07C59/42 ,  C07C51/493 ,  A61K31/201 ,  A61P35/00 ,  A61P9/00

CPC分类号： C07C59/42 ,  C07B2200/07 ,  C07C51/493

摘要： This invention refers to the synthesis and purification of a hydroxide derivative of fatty acids, as well as to the separation method of its enantiomers (or optic isomers) [-] and [+], to the enantiomer [-], to pharmaceutical compositions which include it, and to its use as medicines, as well as to an in vitro method of diagnosis/prognosis and evaluation of the potential use of the molecule of the invention in different pathologies, as well as its use for the regulation of certain enzymes and the study of their activity and effects.

摘要翻译： 2-羟基丙酸酯脂肪酸的对映体。 本发明涉及脂肪酸的2种氢氧化物衍生物的合成和纯化，以及其对映体（或光学异构体）[ - ] y [+]与对映体本身的分离方法，包括它们的药物组合物 ，以及它们作为药物的用途，以及诊断/预后和评价本发明分子在不同病理学中潜在用途的体外方法，以及它们用于调节某些酶的用途以及该研究 他们的活动和效果。

公开(公告)号：EP3287437A1

公开(公告)日：2018-02-28

申请号：EP17191078.9

申请日：2012-10-08

申请人： Universitat de les Illes Balears

发明人： ESCRIBÁ RUIZ, Pablo Vicente ,  MARTÍN, María Laura ,  NOGUERA SALVÀ, María Antònia ,  BUSQUETS XAUBET, Xavier ,  LÓPEZ JIMÉNEZ, David ,  IBARGUREN AIZPITARTE, Maitane ,  SOTO SALVADOR, José Javier ,  YUS ASTIZ, Miguel

IPC分类号： C07C59/42 ,  C07C51/493 ,  A61K31/201 ,  A61P35/00 ,  A61P9/00

摘要： This invention refers to the synthesis and purification of a hydroxide derivative of fatty acids, as well as to the separation method of its enantiomers (or optic isomers) [-] and [+], to the enantiomer [-], to pharmaceutical compositions which include it, and to its use as medicines, as well as to an in vitro method of diagnosis/prognosis and evaluation of the potential use of the molecule of the invention in different pathologies, as well as its use for the regulation of certain enzymes and the study of their activity and effects.

摘要翻译： 本发明涉及脂肪酸的氢氧化物衍生物的合成和纯化，以及其对映异构体（或光学异构体）[ - ]和[+]与对映异构体[ - ]的分离方法， 包括它以及它作为药物的用途，以及体外诊断/预测和评估本发明分子在不同病理学中潜在用途的方法，以及其用于调节某些酶的用途和 他们的活动和效果的研究。

公开(公告)号：EP2774910A1

公开(公告)日：2014-09-10

申请号：EP12838506.9

申请日：2012-10-08

申请人： Universitat de les Illes Balears

发明人： ESCRIBÁ RUIZ, Pablo Vicente ,  BARCELÓ COBLIJN, Gwndolyn ,  MARTÍN, María Laura ,  TERÉS JIMÉNEZ, Silvia ,  NOGUERA SALVÀ, María Antònia ,  BUSQUETS XAUBET, Xavier ,  LÓPEZ JIMÉNEZ, David ,  IBARGUREN AIZPITARTE, Maitane ,  SOTO SALVADOR, José Javier ,  YUS ASTIZ, Miguel

IPC分类号： C07C59/42 ,  C07C51/493 ,  A61K31/201 ,  A61P35/00 ,  A61P9/00

CPC分类号： C07C59/42 ,  C07B2200/07 ,  C07C51/493

摘要： Enantiomers of 2-hydroxiderivates of fatty acids. This invention refers to the synthesis and purification of 2 hydroxide derivatives of fatty acids, as well as to the separation method of its enantiomers (or optic isomers) [-] y [+], to the enantiomers themselves, to pharmaceutical compositions which include them, and to their use as medicines, as well as to an in vitro method of diagnosis/prognosis and evaluation of the potential use of the molecules of the invention in different pathologies, as well as their use for the regulation of certain enzymes and the study of their activity and effects.