利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

9 条记录 (耗时 0.016 秒)

    PROCEDE DE DEDOUBLEMENT DE SELS DE L'OMEPRAZOLE
    1.
    发明公开
    PROCEDE DE DEDOUBLEMENT DE SELS DE L'OMEPRAZOLE 有权
    用于光学分离奥美拉唑盐

    公开(公告)号：EP2185543A2

    公开(公告)日：2010-05-19

    申请号：EP08828432.8

    申请日：2008-08-29

    申请人： UNIVERSITE DE ROUEN

    发明人： COQUEREL, Gérard ,  TAUVEL, Guillaume ,  PETIT, Marie-Noelle

    IPC分类号： C07D401/12 ,  A61K31/4439 ,  A61P1/04 ,  C07D235/28 ,  C07D213/68

    CPC分类号： C07D401/12

    摘要： The present invention relates to the resolution by preferential crystallization of potassium salts of racemic omeprazole which is a solvate of ethanol and/or of ethylene glycol, which consists in converting the omeprazole to the potassium salt in the form of a solvate or of a mixture of these solvates in the presence of an excess of inorganic base which is a source of potassium, the said potassium salts existing in the form of conglomerates, and in then resolving the said conglomerates, independently or simultaneously, by preferential crystallization in order to separate the two (S) and (R) enantiomers of these potassium salts of omeprazole.

    PROCEDE DE DEDOUBLEMENT DE DEUX ANTIPODES OPTIQUES PAR CRISTALLISATION
    5.
    发明公开
    PROCEDE DE DEDOUBLEMENT DE DEUX ANTIPODES OPTIQUES PAR CRISTALLISATION 失效
    方法通过结晶对映体的光学SPLIT

    公开(公告)号：EP0720595A1

    公开(公告)日：1996-07-10

    申请号：EP94928427.0

    申请日：1994-09-22

    申请人： UNIVERSITE DE ROUEN

    发明人： COQUEREL, Gérard ,  PETIT, Marie-Noelle ,  BOUAZIZ, Roger

    IPC分类号： C07B57 ,  C07C29 ,  C07C31 ,  C07D233

    CPC分类号： C07D233/76 ,  C07B57/00 ,  C07C29/78 ,  C07D233/74

    摘要： A method of optical enantiomer resolution by preferential crystallization involves entering, each time crystallization starts, the two-phase domain containing excess enantiomer and the saturated solution, and cooling according to a well-defined kinetic schedule. A racemic mixture of fine particle size is added to the mother liquors obtained after harvesting the crystals, the mother liquors then being heated to a temperature lower than that of homogenization of the solution so that excess enantiomer is present only in a solid state in equilibrium with the solution. Further cooling produces the other enantiomer and completes the cycle of operations which may then be carried out repetitively.

    PROCÉDÉ DE MESURE DE DIFFRACTION DES RAYONS X, SES APPLICATIONS ET DISPOSITIF DE MISE EN OEUVRE
    6.
    发明公开
    PROCÉDÉ DE MESURE DE DIFFRACTION DES RAYONS X, SES APPLICATIONS ET DISPOSITIF DE MISE EN OEUVRE 有权
    安德鲁·维也纳执行秘书长VERFAHREN ZUR MESSUNG DER STREUUNG VONRÖNTGENSTRAHLEN，ANWENDUNGSVERFAHREN UND IMPLEMENTIERUNGSVORRICHTUNG

    公开(公告)号：EP2694953A1

    公开(公告)日：2014-02-12

    申请号：EP12717425.8

    申请日：2012-04-02

    申请人： Universite de Rouen

    发明人： COQUEREL, Gérard ,  SANSELME, Morgane ,  LAFONTAINE, Anaïs

    IPC分类号： G01N23/20 ,  G01N23/207

    CPC分类号： G01N23/203 ,  G01N23/20 ,  G01N23/20033 ,  G01N23/207 ,  G01N2223/056 ,  G01N2223/1016 ,  G01N2223/602 ,  G01N2223/639

    摘要： Method of measuring scattering of X-rays, characterized in that a compound to be analyzed is installed in a receptacle (1) comprising a flat bottom permeable to X-rays, in that an analysis by scattering of the X-rays is carried out by sending a stream of X-rays upwards in the direction of said bottom permeable to the X-rays and by measuring the stream of scattered X-rays that is reflected downwards, and in that a thermostatically controlled fluid at the same temperature as that of the compound to be analyzed in the receptacle is projected towards the flat bottom (3) permeable to X-rays, from outside the receptacle (1), and device for measuring scattering of X-rays characterized in that it comprises a receptacle (1) comprising a bottom shut off by a membrane (3) transparent to X-rays, as well as a diffractometer whose goniometer (4, 5) is installed so as to direct a beam of X-rays from below towards the membrane (3) transparent to X-rays and the detector (5) being installed for the measurement of the X-rays scattered therebelow.

    摘要翻译： 本发明涉及一种用于测量X射线散射的方法和装置，其中待分析的化合物被安装在包括X射线透过的平底的容器中，其中X射线衍射分析是通过发送 X射线向上朝向所述X射线透射底部并通过测量向下反射的散射X射线流，并且其中恒定地控制到与在容器中分析的化合物相同的温度的流体被投射向 X射线透过的平底，从容器外面。