利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

19 条记录 (耗时 0.012 秒)

    CONTROLLED DELIVERY SYSTEM FOR BIOACTIVE SUBSTANCES
    3.
    发明授权
    CONTROLLED DELIVERY SYSTEM FOR BIOACTIVE SUBSTANCES 有权
    具有控释生物活性剂体系

    公开(公告)号：EP1545455B1

    公开(公告)日：2008-04-30

    申请号：EP03769327.2

    申请日：2003-09-24

    申请人： Universiteit Gent

    发明人： REMON, Jean Paul ,  MEHUYS, Els ,  VERVAET, Chris

    IPC分类号： A61K9/00 ,  A61K9/22 ,  A61K9/36

    CPC分类号： A61K9/2054 ,  A61K9/2013 ,  A61K9/2866

    摘要： A biologically active composite solid shaped article comprising: (a) an outer layer, and (b) an inner core filling the said outer layer and comprising: - at least a biologically active ingredient, and - an excipient comprising at least a hydrophilic cellulose polymer and an amphiphilic material in the form of a blend with the said hydrophilic cellulose polymer, the weight ratio of the hydrophilic cellulose polymer to the amphiphilic material being from 0.2:1 to 0.6:1, provides improved sustained release of the biologically active ingredient.

    CONTROLLED DELIVERY SYSTEM FOR BIOACTIVE SUBSTANCES
    4.
    发明公开
    CONTROLLED DELIVERY SYSTEM FOR BIOACTIVE SUBSTANCES 有权
    具有控释生物活性剂体系

    公开(公告)号：EP1545455A1

    公开(公告)日：2005-06-29

    申请号：EP03769327.2

    申请日：2003-09-24

    申请人： UNIVERSITEIT GENT

    发明人： REMON, Jean Paul ,  MEHUYS, Els ,  VERVAET, Chris

    IPC分类号： A61K9/00 ,  A61K9/22 ,  A61K9/36

    CPC分类号： A61K9/2054 ,  A61K9/2013 ,  A61K9/2866

    摘要： A biologically active composite solid shaped article comprising: (a) an outer layer, and (b) an inner core filling the said outer layer and comprising: - at least a biologically active ingredient, and - an excipient comprising at least a hydrophilic cellulose polymer and an amphiphilic material in the form of a blend with the said hydrophilic cellulose polymer, the weight ratio of the hydrophilic cellulose polymer to the amphiphilic material being from 0.2:1 to 0.6:1, provides improved sustained release of the biologically active ingredient.

    AQUEOUS COACERVATE COMPOSITION COMPRISING POORLY WATER-SOLUBLE BIOLOGICALLY-ACTIVE AGENTS
    8.
    发明公开
    AQUEOUS COACERVATE COMPOSITION COMPRISING POORLY WATER-SOLUBLE BIOLOGICALLY-ACTIVE AGENTS 审中-公开
    重水水溶性生物制剂水凝聚成分

    公开(公告)号：EP2376061A1

    公开(公告)日：2011-10-19

    申请号：EP10702263.4

    申请日：2010-01-13

    申请人： Universiteit Gent

    发明人： REMON, Jean Paul ,  VERVAET, Chris ,  DA FONSECA ANTUNES, Andre Bruno

    IPC分类号： A61K9/10 ,  A61K31/7048 ,  A61K9/16

    CPC分类号： A61K9/10 ,  A61K9/1694 ,  A61K31/00 ,  A61K31/155

    摘要： This invention relates to an aqueous gelatin-free, egg portion-free, two-phase coacervate composition comprising a coacervate phase and an equilibrium water phase, comprising, per 100 parts by weight, a mixture of: (a) from 2 to 30 parts by weight of a poorly water-soluble bio-active agent, (b) from 5 to 55 parts by weight of a polysaccharide-free tensio-active system with a HLB from 8 to 18 and consisting of non-ionic tensio-active agents, (c) from 2 to 40 parts by weight of one or more water-soluble carriers for said poorly water-soluble bio-active agent, said carriers being selected from the group consisting of maltodextrins with a molecular weight below 1,800, erythritol, xylitol, sorbitol, mannitol, maltitol, isomalt and lactitol, and (d) from 20 to 85 parts by weight of water, wherein the weight ratio (c)/(b) of the water-soluble carriers to the non-ionic tensio- active agents in the said mixture is from 0.005/1 to 3.5/1. Such coacervate compositions may be dried into solid dosage forms from which rapid release of the bio-active agent can be obtained.

    ORAL DOSAGE FORM
    9.
    发明公开
    ORAL DOSAGE FORM 审中-公开

    公开(公告)号：EP3892263A1

    公开(公告)日：2021-10-13

    申请号：EP21173550.1

    申请日：2017-03-24

    申请人： Universiteit Gent

    发明人： VERVAET, Chris ,  REMON, Jean Paul ,  VERSTRAETE, Glenn

    IPC分类号： A61K9/16 ,  A61K45/06 ,  A61K9/20

    摘要： The present invention in general relates to a pharmaceutical dosage form comprising one or more granules, and a method for manufacturing thereof. The granules of the dosage form are prepared via the extrusion/spheronization technique using partially hydrolysed polyvinyl alcohol. These granules have the advantage that a high drug load can be contained therein.