公开(公告)号：EP2854776B1

公开(公告)日：2020-02-12

申请号：EP13726776.1

申请日：2013-05-31

申请人： University College Dublin National University Of Ireland, Dublin

发明人： LEE, Gil ,  O'MAHONY, James ,  PLATT, Mark

IPC分类号： A61K9/50 ,  B01J13/04 ,  B01J13/12 ,  H01F1/00 ,  A61B5/055

公开(公告)号：EP2854776A2

公开(公告)日：2015-04-08

申请号：EP13726776.1

申请日：2013-05-31

申请人： University College Dublin National University Of Ireland, Dublin

发明人： LEE, Gil ,  O'MAHONY, James ,  PLATT, Mark

IPC分类号： A61K9/50 ,  B01J13/04

摘要： There is provided a method of producing microparticles using an emulsion based synthesis route including: Providing a first fluid phase and a second fluid phase, wherein the first fluid phase is a continuous phase and the second fluid phase is a dispersed phase comprising a dispersed material, wherein the continuous phase is immiscible with the dispersed phase; Mixing the first continuous phase and the second dispersed phase in the presence of a surfactant in a shear device to form an emulsion of droplets of controllable size and having a narrow drop size distribution; Drying the emulsion to form microparticles of controllable size and having narrow size distribution, and wherein the microparticles may comprise spherical, crumpled, dimpled, porous or hollow microparticles morphology. Also provided is a system including shear device and drying arrangement. Also provided are micro particles of controllable size and morphology formed by the method.

摘要翻译： 提供了使用基于乳液的合成途径制备微粒的方法，包括：提供第一流体相和第二流体相，其中第一流体相是连续相，第二流体相是包含分散材料的分散相， 其中连续相与分散相不混溶; 在剪切装置中在存在表面活性剂的情况下将第一连续相和第二分散相混合以形成可控尺寸并具有窄液滴尺寸分布的液滴的乳液; 干燥乳液以形成尺寸可控并且具有窄尺寸分布的微粒，并且其中微粒可以包含球形，皱巴巴的，凹陷的，多孔的或中空的微粒形态。 还提供了包括剪切装置和干燥装置的系统。 还提供了通过该方法形成的可控尺寸和形态的微粒。