公开(公告)号：EP2590682A1

公开(公告)日：2013-05-15

申请号：EP11738467.7

申请日：2011-07-11

申请人： University College London

发明人： UCHEGBU, Ijeoma ,  SCHATZLEIN, Andreas ,  MAZZA, Mariarosa

IPC分类号： A61K47/48 ,  A61P25/00

CPC分类号： A61K47/48046 ,  A61K9/0019 ,  A61K9/0092 ,  A61K9/08 ,  A61K38/00 ,  A61K47/48092 ,  A61K47/542 ,  A61K47/543 ,  A61K47/549

摘要： A composition comprises nanofibres for the delivery of a peptide across the blood brain barrier in a method of therapy of the human or animal body, wherein the nanofibres comprise a peptide conjugated to a lipophilic group. Further, a compound comprises a Dalargin or a derivative having one or more substituted, deleted or inserted aminoacyl units, and, conjugated to an aminoacyl group preferably via a side chain, a lipophilic group, optionally via a linker.

公开(公告)号：EP1543040B1

公开(公告)日：2019-02-13

申请号：EP03748286.6

申请日：2003-09-22

申请人： University College London

发明人： UCHEGBU, Ijeoma ,  SCHATZLEIN, Andreas ,  STEWART, Ailsa ,  WILSON, Clive

IPC分类号： C08B37/08 ,  A61K47/34 ,  A61K9/20