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公开(公告)号：EP3504220A1
公开(公告)日：2019-07-03
申请号：EP17758915.7
申请日：2017-08-23
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公开(公告)号：EP3183226A1
公开(公告)日：2017-06-28
申请号：EP15756216.6
申请日：2015-08-19
摘要： A method of depolymerising a lignin includes oxidising the lignin to provide an oxidised lignin wherein benzylic —OH of β-O-4 linkages have been converted to carbonyl. The oxidised lignin is depolymerised with a metal selected from the group consisting of zinc, magnesium, aluminium and titanium or mixtures thereof, in the presence of an ammonium salt or carbon dioxide. Also described are methods for manufacturing phenolic products from lignin and a method for the cleavage of a β-O-4 linkage in a substrate.
摘要翻译： 解聚木质素的方法包括氧化木质素以提供氧化的木质素，其中β-O-4键的苄基-OH已经转化为羰基。 氧化的木质素在铵盐或二氧化碳存在下用选自锌，镁，铝和钛或其混合物的金属解聚。 还描述了从木质素制备酚类产物的方法和用于在底物中裂解β-O-4键的方法。
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公开(公告)号：EP3183226B1
公开(公告)日：2020-01-15
申请号：EP15756216.6
申请日：2015-08-19
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4.发明授权
公开(公告)号：EP2099445B1
公开(公告)日：2010-11-17
申请号：EP07804108.4
申请日：2007-09-04
申请人： University Court of The University of Dundee , UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS
发明人： LAIN, Sonia , LANE, David Phillip , STARK, Michael John Raymond , MCCARTHY, Anna Rose , HOLLICK, Jonathan James , WESTWOOD, Nicholas James
IPC分类号： A61K31/17
CPC分类号： C07D295/155 , C07C275/54 , C07C335/26 , C07D295/15
摘要： The present invention relates to compounds which acivate the p53 response, and find use in, for example, hyperproliferative diseases such as cancer treatment and potentially other diseases/conditions (involving sirtuin function).
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公开(公告)号：EP1776345A2
公开(公告)日：2007-04-25
申请号：EP05754350.6
申请日：2005-06-08
IPC分类号： C07D231/00
CPC分类号： C07D231/56
摘要： There is provided a method to convert O-functionalized indazolinone-derivatives to the corresponding N2-functinoalised indazolinone derivatives, by use of microwave energy or a transition metal catalyst. A preferred catalyst is palladium tetrakis. The method described allows the creation of a library of chemical compounds which can be screened for biological activity.
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6.发明授权
公开(公告)号：EP1776345B1
公开(公告)日：2013-02-13
申请号：EP05754350.6
申请日：2005-06-08
IPC分类号： C07D231/00
CPC分类号： C07D231/56
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7.发明公开
公开(公告)号：EP2099445A2
公开(公告)日：2009-09-16
申请号：EP07804108.4
申请日：2007-09-04
申请人： University Court of The University of Dundee , UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS
发明人： LAIN, Sonia , LANE, David Phillip , STARK, Michael John Raymond , MCCARTHY, Anna Rose , HOLLICK, Jonathan James , WESTWOOD, Nicholas James
IPC分类号： A61K31/17
CPC分类号： C07D295/155 , C07C275/54 , C07C335/26 , C07D295/15
摘要： The present invention relates to compounds which acivate the p53 response, and find use in, for example, hyperproliferative diseases such as cancer treatment and potentially other diseases/conditions (involving sirtuin function).
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