公开(公告)号：EP2900697B1

公开(公告)日：2020-08-05

申请号：EP13841990.8

申请日：2013-09-27

申请人： University Of British Columbia

发明人： WANG, Yu Tian ,  FAN, Xuelai ,  JIN, Jack Wuyang

IPC分类号： C07K19/00 ,  C07K14/16 ,  C07K14/435 ,  C07K14/47 ,  A61K38/16 ,  A61K38/00 ,  A61K38/17 ,  A61K38/48 ,  A61K38/58 ,  A61K31/00 ,  A61K31/37 ,  A61K31/4365 ,  C12N9/12 ,  A61P9/00 ,  A61P21/00 ,  A61P25/00 ,  A61P43/00

公开(公告)号：EP4291245A1

公开(公告)日：2023-12-20

申请号：EP22748778.2

申请日：2022-02-08

申请人： University Of British Columbia

发明人： WANG, Yu Tian ,  JIN, Jack ,  FAN, Xuelai

IPC分类号： A61K47/66 ,  A61P25/00 ,  A61P25/16 ,  A61P25/28 ,  C07K14/00 ,  C07K14/16 ,  C07K19/00 ,  C12N15/62 ,  C07K14/47

公开(公告)号：EP2900697A1

公开(公告)日：2015-08-05

申请号：EP13841990.8

申请日：2013-09-27

申请人： University Of British Columbia

发明人： WANG, Yu Tian ,  FAN, Xuelai ,  JIN, Wu Yang

IPC分类号： C07K19/00 ,  A61K38/16 ,  C07K14/16 ,  C07K14/435 ,  C07K14/47

摘要： In one aspect, the invention provides a peptide comprising a chaperone-mediated autophagy (CMA)-targeting signal domain; a protein-binding domain that selectively binds to a target cytosolic protein; and a cell membrane penetrating domain (CMPD). In another aspect, the invention provides methods for reducing the intracellular expression level of an endogenous target protein in vitro and in an animal, wherein the method involves administration of the peptide. Methods are also provided for treating a pathological condition in an animal, the methods comprising administering the peptide to the animal. In one embodiment, the pathological condition is a neurodegenerative disease. In another embodiment of the invention, the target cytosolic protein is death associated protein kinase 1 and the CMPD is protein transduction domain of the HIV-1 Tat protein.