公开(公告)号：EP2950785A2

公开(公告)日：2015-12-09

申请号：EP14746863.1

申请日：2014-02-04

申请人： University Of Notre Dame Du Lac

发明人： BILGICER, Zihni Basar ,  ASHLEY, Jonathan ,  KIZILTEPE-BILGICER, Tanyel ,  STEFANICK, Jared ,  ALVES, Nathan

IPC分类号： A61K9/127 ,  A61K38/00 ,  A61K47/48 ,  A61P35/00

CPC分类号： A61K47/48815 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/008 ,  A61K9/1271 ,  A61K9/2054 ,  A61K9/4858 ,  A61K38/05 ,  A61K38/07 ,  A61K47/542 ,  A61K47/62 ,  A61K47/6911

摘要： The invention provides pharmaceutical compositions and method of using the compositions, wherein the compositions comprise liposomes or micelles that contain one or more targeting peptides and/or anticancer drugs. In various embodiments, the components of the liposomes can include a) a phospholipid and optionally a lipid that is not a phospholipid; b) a pegylated lipid; c) a peptide-ethylene glycol (EG)-lipid conjugate wherein the peptide is a targeting ligand, and d) one or more drug-conjugated lipid, encapsulated drugs, or a combination thereof. The peptide- EG-lipid conjugate can be, for example, a compound of Formula (I) or Formula (II). The ethylene glycol (EG) segments of the peptide-EG-lipid conjugate can be, for example, EG6 to about EG36; and the EG segment can be conjugated to one or more lysine moieties.