公开(公告)号：EP3247414B1

公开(公告)日：2018-11-21

申请号：EP16702008.0

申请日：2016-01-22

申请人： University Of The Free State

发明人： BESTER, Dreyer ,  SMIT, Francis Edwin ,  VAN DEN HEEVER, Johannes ,  BOTES, Lezelle ,  DOHMEN, Pascal Maria Chris Eugène

IPC分类号： A61L27/36

CPC分类号： A61L27/3687 ,  A01N25/02 ,  A01N43/16 ,  A01N43/90 ,  A61L2430/40

摘要： This invention relates to method of detoxification and stabilization of implantable or transplantable biological material of human or animal origin, the method including the following steps: treatment of the material with an antibiotic solution; treatment of the material in a solution containing an organic acid surfactant bile acid; treatment of the material in a solution to remove the organic acid surfactant bile acid; and treatment of the material in a primary alcohol such as ethanol. The solution containing an organic acid surfactant bile acid contains a synergistic triple combination of the organic acid surfactant bile acid, an anionic surfactant, and a non-ionic surfactant.

公开(公告)号：EP3247414A1

公开(公告)日：2017-11-29

申请号：EP16702008.0

申请日：2016-01-22

申请人： University Of The Free State

发明人： BESTER, Dreyer ,  SMIT, Francis Edwin ,  VAN DEN HEEVER, Johannes ,  BOTES, Lezelle ,  DOHMEN, Pascal Maria Chris Eugène

IPC分类号： A61L27/36

CPC分类号： A61L27/3687 ,  A01N25/02 ,  A01N43/16 ,  A01N43/90 ,  A61L2430/40

摘要： This invention relates to method of detoxification and stabilization of implantable or transplantable biological material of human or animal origin, the method including the following steps: treatment of the material with an antibiotic solution; treatment of the material in a solution containing an organic acid surfactant bile acid; treatment of the material in a solution to remove the organic acid surfactant bile acid; and treatment of the material in a primary alcohol such as ethanol. The solution containing an organic acid surfactant bile acid contains a synergistic triple combination of the organic acid surfactant bile acid, an anionic surfactant, and a non-ionic surfactant.