公开(公告)号：EP2164965A2

公开(公告)日：2010-03-24

申请号：EP08763141.2

申请日：2008-05-29

申请人： University Of The Witwatersrand, Johannesburg

发明人： PATRICK, Arbuthnot ,  ELY, Abdullah ,  NAIDOO, Tanusha ,  WEINBERG, Marc Saul ,  LONGSHAW, Victoria Mary

IPC分类号： C12N15/11 ,  A61K31/713

CPC分类号： C12N15/111 ,  C12N15/1131 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2320/50

摘要： This invention relates to inhibition of hepatitis gene expression. More specifically, the invention relates to a method of using RNA sequences to inhibit Hepatitis B and C Virus replication. Expression cassettes that include DNA sequences derived from endogenous micro RNAs (miRs) are used in the method and are transcribed by Pol Il promoters, and then processed to generate sequences that are specific to target hepatitis virus sequences (RNAi effecter sequences). The RNAi effecter sequences can target the selected hepatitis virus sequences resulting in gene silencing or transcriptional inhibition of the hepatitis virus gene. The expression cassettes may be delivered in vitro or in vivo to host cells. A pharmaceutical composition containing the expression cassettes is also claimed.

公开(公告)号：EP2164965B1

公开(公告)日：2013-09-11

申请号：EP08763141.2

申请日：2008-05-29

申请人： University Of The Witwatersrand, Johannesburg

发明人： PATRICK, Arbuthnot ,  ELY, Abdullah ,  NAIDOO, Tanusha ,  WEINBERG, Marc Saul ,  LONGSHAW, Victoria Mary

IPC分类号： C12N15/113 ,  A61K31/713

CPC分类号： C12N15/111 ,  C12N15/1131 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2320/50