公开(公告)号：EP3116898A1

公开(公告)日：2017-01-18

申请号：EP15761543.6

申请日：2015-03-11

申请人： University of Florida Research Foundation, Inc.

发明人： MCFADDEN, Douglas Grant ,  LEWIN, Alfred S. ,  LUCAS, Alexandra Rose ,  ILDEFONSO, Cristhian J. ,  RAHMAN, Mohammed Masmudur

IPC分类号： C07K14/065

CPC分类号： C07K14/005 ,  A61K9/0048 ,  A61K38/162 ,  A61K48/00 ,  A61K48/005 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/24022 ,  C12N2750/14143

摘要： Disclosed are methods and compositions for preventing, treating, and/or ameliorating one or more symptoms of inflammation in a mammal. In particular, viral vectors and medicaments containing them are disclosed, which are useful in the prophylaxis, therapy, or amelioration of symptoms of one or more inflammatory-mediated mammalian diseases, such as age-related macular degeneration (AMD), arthritis, Bechet's disease, Best macular dystrophy, corneal inflammation, diabetic retinopathy, drusen formation, dry AMD, dry eye, geographic atrophy, glaucomaocular neovascularization, Lupus erythematosus, macular degeneration, Mallatia Leventinese and Doyne honeycomb retinal dystrophy, nephritis, ocular hypertension, ocular inflammation, recurrent uveitis, Sorsby fundus dystrophy, vasculitis, vitreoretinopathy, wet AMD, or related disorders. In exemplary methods, administration of a pharmaceutical composition comprising a recombinant viral vector that delivers a secretable and cell-penetrating M013 protein or peptide to a subject in need thereof facilitated treatment of particular human disorders such as AMD, ocular neovascularization, uveitis, and related inflammatory ocular disease.

摘要翻译： 公开了用于预防，治疗和/或改善哺乳动物中一种或多种炎症症状的方法和组合物。 特别地，公开了含有它们的病毒载体和药物，其可用于预防，治疗或改善一种或多种炎症介导的哺乳动物疾病的症状，例如年龄相关性黄斑变性（AMD），关节炎，Bechet氏病 ，最佳黄斑营养不良症，角膜炎，糖尿病性视网膜病变，玻璃疣形成，干性AMD，干眼症，地域性萎缩，青光眼新生血管形成，红斑狼疮，黄斑变性，马拉维亚Leventinese和Doyne蜂窝状视网膜营养不良，肾炎，眼高压，眼部炎症，复发性葡萄膜炎 ，Sorsby眼底营养不良，血管炎，玻璃体视网膜病变，湿性AMD或相关疾病。 在示例性方法中，包含向有需要的受试者递送可分泌和细胞穿透的M013蛋白或肽的重组病毒载体的药物组合物的给药有助于治疗特定的人类疾病如AMD，眼新生血管形成，葡萄膜炎和相关炎症 眼病。