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公开(公告)号：EP1651771A2
公开(公告)日：2006-05-03
申请号：EP04780197.2
申请日：2004-08-05
IPC分类号： C12Q1/00
摘要： Method and assay systems for analyzing effects of chemical and cellular agents on brain cell neurogenesis in vivo, comprising administering an agent to a test animal and determining responses of cells of brain marrow tissues, including irradiated brain marrow tissue depleted of neurogenic stems cells, and cells in brain marrow-derived neurospheres cultured in vitro.
摘要翻译： 用于分析化学和细胞试剂对体内脑细胞神经发生的作用的方法和测定系统，包括向试验动物施用试剂并测定脑部骨髓组织细胞的应答，所述细胞包括经辐射的耗尽神经原性干细胞的脑部组织和细胞 在体外培养的脑髓源神经球中。
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公开(公告)号：EP1682075A2
公开(公告)日：2006-07-26
申请号：EP04810542.3
申请日：2004-11-05
IPC分类号： A61K6/00
CPC分类号： C12N5/0623 , C12N2500/84 , C12N2501/11 , C12N2501/115
摘要： Systems and methods have been developed for large-scale propagation and differentiation of populations of neurons and glia from neural precursor cells derived from postnatal brain. Under culture conditions containing pituitary extract and mitogenic factors, cells derived from neural stem cells can be attached to a substrate, maintained and serially passaged in culture. Upon removal of mitogenic factors, clusters of neural progenitor cells can be induced that co-express markers of neural stem cells and immature neurons. Unlimited numbers of cells at characterized stages of neurogenesis can be produced. Upon maturation, neuronal cells extend processes and differentiate into mature neuronal phenotypes capable of generating action potentials.
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