-
公开(公告)号：EP3146051A1
公开(公告)日：2017-03-29
申请号：EP15795373.8
申请日：2015-05-20
IPC分类号： C12N15/113
摘要： The present invention is directed to RNA interference (RNAi) molecules targeted against a Huntington's disease nucleic acid sequence, and methods of using these RNAi molecules to treat Huntington's disease.
摘要翻译： 本发明涉及针对亨廷顿氏病核酸序列的RNA干扰（RNAi）分子，以及使用这些RNAi分子治疗亨廷顿氏病的方法。
-
公开(公告)号：EP2970969A1
公开(公告)日：2016-01-20
申请号：EP14769821.1
申请日：2014-03-06
CPC分类号： A61K48/005 , C07K14/47 , C12N15/86 , C12N2750/14143 , C12N2830/008
摘要： An isolated promoter sequence comprising a nucleic acid of between 600 and 1700 nucleotides in length having at least 90% identity to SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:6, or SEQ ID NO:7.
摘要翻译： 分离的启动子序列包含长度为600-1700个核苷酸，与SEQ ID NO：1，SEQ ID NO：2，SEQ ID NO：3，SEQ ID NO：4，SEQ ID NO：1具有至少90％同一性的核酸 5，SEQ ID NO：6或SEQ ID NO：7。
-
公开(公告)号：EP3146051B8
公开(公告)日：2019-11-27
申请号：EP15795373.8
申请日：2015-05-20
IPC分类号： C12N15/113 , A61K31/7088
-
公开(公告)号：EP3146051B1
公开(公告)日：2019-09-04
申请号：EP15795373.8
申请日：2015-05-20
IPC分类号： C12N15/113 , A61K31/7088
摘要： The present invention is directed to RNA interference (RNAi) molecules targeted against a Huntington's disease nucleic acid sequence, and methods of using these RNAi molecules to treat Huntington's disease.
-
公开(公告)号：EP2164967A2
公开(公告)日：2010-03-24
申请号：EP08756453.0
申请日：2008-05-29
IPC分类号： C12N15/11 , A61K31/713
CPC分类号： C12N15/113 , C12N15/111 , C12N2310/14 , C12N2310/141 , C12N2310/531 , C12N2320/30 , C12N2320/53 , C12N2330/51
摘要： The present invention is directed to RNA interference (RNAi) molecules targeted against a nucleic acid sequence, and methods of using these RNAi molecules to reduce off-target toxicity.
-
公开(公告)号：EP2870237B1
公开(公告)日：2018-09-26
申请号：EP13812649.5
申请日：2013-03-14
IPC分类号： C12N15/86
CPC分类号： C12N15/86 , C12N2750/14141 , C12N2750/14143 , C12N2830/38
摘要： An adeno-associated virus filler component comprising a nucleic acid of between 3300 and 4200 nucleotides in length is disclosed.
-
7.发明授权REDUCTION OF OFF-TARGET RNA INTERFERENCE TOXICITY 有权REDUZIERUNG VON OFF-TARGET-RNA-INTERFERENZ-TOXIZITÄT
公开(公告)号：EP2164967B1
公开(公告)日：2015-07-08
申请号：EP08756453.0
申请日：2008-05-29
IPC分类号： C12N15/113 , A61K31/713
CPC分类号： C12N15/113 , C12N15/111 , C12N2310/14 , C12N2310/141 , C12N2310/531 , C12N2320/30 , C12N2320/53 , C12N2330/51
摘要： The present invention is directed to RNA interference (RNAi) molecules targeted against a nucleic acid sequence, and methods of using these RNAi molecules to reduce off-target toxicity.
摘要翻译： 本发明涉及针对核酸序列的RNA干扰（RNAi）分子，以及使用这些RNAi分子降低靶外毒性的方法。
-
8.发明公开RNA INTERFERENCE SUPPRESSION OF NEURODEGENERATIVE DISEASES AND METHODS OF USE THEREOF 审中-公开RNA干扰抑制神经变性疾病和其使用方法
公开(公告)号：EP2152874A2
公开(公告)日：2010-02-17
申请号：EP08747035.7
申请日：2008-04-28
IPC分类号： C12N15/11 , A61K31/713
CPC分类号： C12N15/113 , A61K48/00 , C12N7/00 , C12N15/86 , C12N2310/111 , C12N2310/14 , C12N2310/141 , C12N2310/53 , C12N2310/531 , C12N2320/30 , C12N2320/34 , C12N2750/14143
摘要： The present invention is directed to RNA interference (RNAi) molecules targeted against a nucleic acid sequence that encodes poly-glutamine repeat diseases, and methods of using these RNAi molecules.
-
公开(公告)号：EP2970969B1
公开(公告)日：2020-05-06
申请号：EP14769821.1
申请日：2014-03-06
-
-
-
-
-
-
-
-
搜索结果
9 条记录 (耗时 0.016 秒)
