公开(公告)号：EP3390421A1

公开(公告)日：2018-10-24

申请号：EP16816372.3

申请日：2016-12-19

申请人： University of Leeds

发明人： MARSDEN, Stephen Philip ,  MCGOWAN, Patrick Columba ,  LANARO, Roberta ,  BLACKER, Andrew John

IPC分类号： C07F17/00

CPC分类号： C07F15/0033 ,  B01J31/1815 ,  B01J31/2433 ,  B01J2531/822 ,  B01J2531/827 ,  C07F15/0073 ,  C07F17/00

摘要： Metal complexes such as those of formula (I) are contemplated by the present invention. The metal complexes may be used in catalytic reactions as a catalyst. The catalytic reaction may be an autotransfer process, for example hydrogen borrowing. Improved catalytic activity has been observed with certain metal complexes of the invention.

公开(公告)号：EP3390421B1

公开(公告)日：2020-01-29

申请号：EP16816372.3

申请日：2016-12-19

申请人： University of Leeds

发明人： MARSDEN, Stephen Philip ,  MCGOWAN, Patrick Columba ,  LANARO, Roberta ,  BLACKER, Andrew John

IPC分类号： C07F17/00

公开(公告)号：EP1534723A1

公开(公告)日：2005-06-01

申请号：EP03762793.2

申请日：2003-07-04

申请人： THE UNIVERSITY OF LEEDS

发明人： MCGOWAN, Patrick Columba ,  KNOX, Richard J.

IPC分类号： C07F17/00

CPC分类号： C07F17/00

摘要： The invention provides metallocene compounds of formula (1) for use as medicaments in the treatment of cancer. Formula (1) wherein R1, R2, R3 and R4 represent a combination of H, alkyl, aryl or trimethylsilyl; L represents side chain substituents, at least one of which contains a group which enables the compound to become water-solubilised; X is halo, alkoxy, acetate or H2O; Y is a counter-ion; and M is a metal. The invention also provides novel compounds of the formula (1) wherein at least one of the groups L comprises aquaternary tetraalkylammonium group. The compounds have been shown to have significantly greater activity in the treatment of cancer than the compounds known from the prior art.