公开(公告)号：EP2918603B1

公开(公告)日：2018-08-29

申请号：EP13853637.0

申请日：2013-11-08

申请人： University of Miyazaki ,  Perseus Proteomics Inc.

发明人： KUROSAWA, Yoshikazu ,  MORISHITA, Kazuhiro ,  ZHANG, Lilin ,  KUROSAWA, Gene ,  MITOMO, Katsuyuki ,  SUDO, Yukio ,  NOMURA, Fumiko ,  UKAI, Yoshinori

IPC分类号： C07K16/28 ,  A61K39/395 ,  A61P35/00 ,  A61P35/02 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12P21/08

CPC分类号： C07K16/2881 ,  A61K2039/505 ,  C07K16/30 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/92

摘要： The present invention provides an antibody, in which the heavy chain first complementarity determining region (VH CDR1), the heavy chain second complementarity determining region (VH CDR2), and the heavy chain third complementarity determining region (VH CDR3) are shown in SEQ ID NOs: 1,2, and 7, respectively, and the light chain first complementarity determining region (VL CDR1), the light chain second complementarity determining region (VL CDR2), and the light chain third complementarity determining region (VL CDR3) are shown in SEQ ID NOs: 4, 5, and 6, respectively.

公开(公告)号：EP2708560A1

公开(公告)日：2014-03-19

申请号：EP12781761.7

申请日：2012-05-07

申请人： Perseus Proteomics Inc. ,  University of Miyazaki

发明人： KUROSAWA, Yoshikazu ,  MORISHITA, Kazuhiro ,  ZHANG, Lilin ,  KUROSAWA, Gene ,  MITOMO, Katsuyuki ,  SUDO, Yukio ,  NOMURA, Fumiko ,  UKAI, Yoshinori

IPC分类号： C07K16/30 ,  A61K39/395 ,  A61P35/02 ,  C12N15/09 ,  C12P21/08

CPC分类号： C07K16/30 ,  C07K16/2881

摘要： An object of present invention is to provide a complete human anti-human TfR antibody, which specifically recognizes human TfR, inhibits the survival or growth of cancer cells that highly express TfR, and has no immunogenicity to humans. The present invention provides an antibody which specifically reacts with human TfR, wherein the antibody comprises any one of the amino acid sequences shown in SEQ ID NOS: 1-3, 7-9, 13-15, 19-21, 25-27, 31-33, 37-39, 43-45, 49-51, 55-57, 61-63, 67-69, 73-75, 79-81, 85-87, 91-93, 97-99, 103-105, 109-111, and 115-117, as each of a heavy chain first complementarity determining region (VH CDR1), a heavy chain second complementarity determining region (VH CDR2), and a heavy chain third complementarity determining region (VH CDR3).

摘要翻译： 本发明的目的是提供一种完全人抗TfR抗体，其特异性识别人TfR，抑制高表达TfR的癌细胞的存活或生长，并且对人类没有免疫原性。 本发明提供与人TfR特异性反应的抗体，其中抗体包含SEQ ID NO： 31-33,37-39,43-45,49-51,55-57,61-63,67-69,73-75,77-81,85-87,91-93,97-99,103- 105，109-111和115-117，作为重链第一互补决定区（VH CDR1），重链第二互补决定区（VH CDR2）和重链第三互补决定区（VH CDR3） 。

公开(公告)号：EP2918603A1

公开(公告)日：2015-09-16

申请号：EP13853637.0

申请日：2013-11-08

申请人： University of Miyazaki ,  Perseus Proteomics Inc.

发明人： KUROSAWA, Yoshikazu ,  MORISHITA, Kazuhiro ,  ZHANG, Lilin ,  KUROSAWA, Gene ,  MITOMO, Katsuyuki ,  SUDO, Yukio ,  NOMURA, Fumiko ,  UKAI, Yoshinori

IPC分类号： C07K16/28 ,  A61K39/395 ,  A61P35/00 ,  A61P35/02 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12P21/08

CPC分类号： C07K16/2881 ,  A61K2039/505 ,  C07K16/30 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/92

摘要： The present invention provides an antibody, in which the heavy chain first complementarity determining region (VH CDR1), the heavy chain second complementarity determining region (VH CDR2), and the heavy chain third complementarity determining region (VH CDR3) are shown in SEQ ID NOs: 1,2, and 7, respectively, and the light chain first complementarity determining region (VL CDR1), the light chain second complementarity determining region (VL CDR2), and the light chain third complementarity determining region (VL CDR3) are shown in SEQ ID NOs: 4, 5, and 6, respectively.

摘要翻译： 本发明提供一种抗体，其中重链第一互补决定区（VH CDR1），重链第二互补决定区（VH CDR2）和重链第三互补决定区（VH CDR3）在SEQ ID NOS：1,2和7，分别示出轻链第一互补决定区（VL CDR1），轻链第二互补决定区（VL CDR2）和轻链第三互补决定区（VL CDR3） 分别为SEQ ID NO：4,5和6。