公开(公告)号：EP3725780A1

公开(公告)日：2020-10-21

申请号：EP18888690.7

申请日：2018-12-11

申请人： University of Tsukuba ,  Board of Regents, The University of Texas System

发明人： NAGASE, Hiroshi ,  SAITOH, Tsuyoshi ,  YANAGISAWA, Masashi ,  IRUKAYAMA, Yoko

IPC分类号： C07D239/10 ,  A61K31/513 ,  A61P3/04 ,  A61P3/10 ,  A61P9/00 ,  A61P21/00 ,  A61P25/00 ,  A61P25/08 ,  A61P25/18 ,  A61P25/24 ,  A61P25/26 ,  A61P43/00 ,  C07D403/12

摘要： The present invention aims to provide a novel low-molecular-weight compound showing an orexin receptor agonist activity and expected to be useful as a prophylactic or therapeutic agent for narcolepsy and the like. The present invention provides a compound represented by the formula (I):

wherein each symbol is as described in the description, or a pharmaceutically acceptable acid addition salt thereof, which has an orexin receptor agonist activity, and an orexin receptor agonist containing the compound or a pharmaceutically acceptable acid addition salt thereof.

公开(公告)号：EP3369736A1

公开(公告)日：2018-09-05

申请号：EP16859938.9

申请日：2016-10-28

申请人： University of Tsukuba

发明人： NAGASE, Hiroshi ,  YAMAMOTO, Naoshi ,  IRUKAYAMA, Yoko ,  SAITOH, Tsuyoshi ,  YANAGISAWA, Masashi ,  NAGUMO, Yasuyuki

IPC分类号： C07D489/06 ,  A61K31/485 ,  A61P25/00 ,  A61P43/00 ,  C07D489/08

CPC分类号： C07D489/08 ,  A61K31/485 ,  A61P25/36 ,  C07D489/02 ,  C07D489/06

摘要： The purpose of the present invention is to provide a compound useful as a prophylactic or therapeutic agent for various diseases and symptoms related to orexin receptors, and a medical usage of the same.
The present invention provides a morphinan derivative represented by the general formula (I) below or a pharmaceutically acceptable acid addition salt thereof, the morphinan derivative having excellent selectivity for and antagonism against orexin receptors and excellent therapeutic and prophylactic effects on drug dependence, and an orexin receptor antagonist and a therapeutic or prophylactic agent for drug dependence each containing it as an active ingredient.

公开(公告)号：EP3309146A1

公开(公告)日：2018-04-18

申请号：EP16807611.5

申请日：2016-06-10

申请人： University of Tsukuba ,  Board of Regents, The University of Texas System

发明人： NAGASE, Hiroshi ,  YANAGISAWA, Masashi ,  SAITOH, Tsuyoshi ,  KUTSUMURA, Noriki ,  IRUKAYAMA, Yoko

IPC分类号： C07C311/37 ,  A61K31/18 ,  A61K31/341 ,  A61K31/36 ,  A61K31/381 ,  A61K31/4164 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4439 ,  A61P3/04 ,  A61P3/10 ,  A61P25/20 ,  A61P25/24 ,  A61P31/04 ,  A61P43/00 ,  C07C311/21 ,  C07C311/29 ,  C07D213/36 ,  C07D213/75 ,  C07D213/81

CPC分类号： C07C311/29 ,  A61K31/18 ,  A61K31/341 ,  A61K31/36 ,  A61K31/381 ,  A61K31/4164 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4439 ,  A61P25/00 ,  A61P43/00 ,  C07C311/21 ,  C07C317/44 ,  C07C335/20 ,  C07C2601/04 ,  C07D213/36 ,  C07D213/75 ,  C07D213/81 ,  C07D233/36 ,  C07D239/10 ,  C07D243/04 ,  C07D295/10 ,  C07D307/54 ,  C07D317/68 ,  C07D333/36 ,  C07D417/04

摘要： The present invention aims to provide a novel low-molecular-weight compound exhibiting an orexin receptor agonist activity and expected to be useful as a prophylactic or therapeutic agent for narcolepsy and the like. The present invention provides a compound represented by the formula (I):

wherein each symbol is as defined in the description, or a pharmaceutically acceptable acid addition salt thereof, which has an orexin receptor agonist activity, and an orexin receptor agonist containing the compound or a pharmaceutically acceptable acid addition salt thereof.

摘要翻译： 本发明的目的在于提供一种显示出食欲肽受体激动剂活性并且预期可用作嗜睡症等的预防或治疗剂的新型低分子量化合物。 本发明提供式（I）表示的化合物或其药学上可接受的酸加成盐，其中每个符号如说明书中所定义，所述化合物或其药学上可接受的酸加成盐具有食欲肽受体激动剂活性，以及​​含有该化合物的食欲肽受体激动剂或 其药学上可接受的酸加成盐。