公开(公告)号：EP3315132A1

公开(公告)日：2018-05-02

申请号：EP16814498.8

申请日：2016-06-24

申请人： University of Tsukuba

发明人： NAGASE, Hiroshi ,  TADA, Makiko ,  YASHIMA, Megumi ,  SAIKI, Takeshi

IPC分类号： A61K31/485 ,  A61K9/70 ,  A61K47/32 ,  A61P17/04

CPC分类号： A61K9/70 ,  A61K31/485 ,  A61K47/32

摘要： The present invention relates to a nalfurafine-containing percutaneous absorption patch having a support, a drug layer and a control layer which are laminated successively, wherein the drug layer contains at least one kind of a drug selected from the group consisting of nalfurafine and a salt thereof, and capable of maintaining a given level of drug skin permeation amount without permeation of an excess amount of the drug through the skin in a short time even when applied to the skin in which the horny cell layer and the like are damaged and the skin barrier is insufficient.

摘要翻译： 本发明涉及一种含有纳福呋喃的经皮吸收贴剂，其具有依次层叠的载体，药物层和对照层，其中药物层含有至少一种选自纳福拉芬和盐 ，即使在角质层等被损伤的皮肤和皮肤损伤的情况下，也能够在短时间内维持规定量的药物皮肤透过量而不会使过量的药物透过皮肤渗透， 屏障不足。