专利检索 ap:("University of Washington through its Center for Commercialization" OR "Cincinnati Children's Hospital Medical Center") AND inv:"DUFFIELD, Jeremy" 第 1 页

1.

发明公开
MOLECULES, COMPOSITIONS AND METHODS TO TREAT ORGAN SCARRING 审中-公开
标题翻译：分子，组合物和方法用于治疗教育机构疤痕

公开(公告)号：EP2914279A2

公开(公告)日：2015-09-09

申请号：EP13851855.0

申请日：2013-11-01

申请人： University of Washington through its Center for Commercialization , Cincinnati Children's Hospital Medical Center

发明人： DUFFIELD, Jeremy , REN, Shuyu , HEGDE, Rashmi

IPC分类号： A61K38/17

CPC分类号： C07K14/4703 , A61K38/1709

摘要： The present disclosure provides molecules, compositions and methods for treating scarring in organs. The molecules, compositions and methods treat scarring by modulating the WNT, platelet-derived growth factor receptor (PDGFR), transforming growth factor-beta (TGF3) and/or connective-tissue growth factor (CTGF) signaling pathways.

摘要翻译： 本发明提供一种分子，组合物和方法在治疗器官疤痕。的分子，组合物和方法通过调制WNT，血小板衍生生长因子受体（PDGFR），转化生长因子-β（TGF3）和/或信号传导途径结缔组织生长因子（CTGF）治疗疤痕。

2.

发明授权
Dikkopf2 (Dkk2) and active fragments thereof for use in the treatment of kidney or pancreas injuries 有权
标题翻译： Dikkopf2（DKK2）和肾或胰腺损伤的治疗中的用途及其活性片段

公开(公告)号：EP2408466B1

公开(公告)日：2015-10-21

申请号：EP10754107.0

申请日：2010-03-18

申请人： The Brigham and Women's Hospital, Inc. , Cincinnati Children's Hospital Medical Center

发明人： DUFFIELD, Jeremy , LANG, Richard A.

IPC分类号： A61K38/16 , A61P43/00 , A61P13/12 , A61P1/18

CPC分类号： A61K38/16 , G01N33/6872 , G01N33/6893

3.

发明公开
Agents and methods for tissue repair and regeneration 有权
标题翻译： Dikkopf2（DKK2）和肾或胰腺损伤的治疗中的用途及其活性片段

公开(公告)号：EP2408466A2

公开(公告)日：2012-01-25

申请号：EP10754107.0

申请日：2010-03-18

申请人： The Brigham and Women's Hospital, Inc. , Cincinnati Children's Hospital Medical Center

发明人： DUFFIELD, Jeremy , LANG, Richard A.

IPC分类号： A61K38/16 , A61K39/395 , A61P1/00 , A61P9/00 , A61P21/00

CPC分类号： A61K38/16 , G01N33/6872 , G01N33/6893

摘要： Methods of treating solid organ injuries using compounds that enhance Wnt signalling are described.