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1.发明公开DISUBSTITUTED PIPERIDINE DERIVATIVES AS BUTYRYLCHOLINESTERASE INHIBITORS FOR USE IN THE TREATMENT OF ALZHEIMER 审中-公开用于治疗阿尔茨海默病的丁酰胆碱酯酶抑制剂的二取代哌啶衍生物
公开(公告)号：EP3256128A1
公开(公告)日：2017-12-20
申请号：EP16720556.6
申请日：2016-03-22
申请人： Univerza v Ljubljani
发明人： BRUS, Boris , KOSAK, Urban , KNEZ, Damijan , COQUELLE, Nicolas , COLLETIER, Jacques-Philippe , GOBEC, Stanislav
IPC分类号： A61K31/445 , A61K31/4523 , A61K31/453 , A61K31/4709 , C07D311/10 , C07D215/26 , C07D277/42 , C07D295/04 , A61P25/28
CPC分类号： C07D211/28 , A61K31/445 , A61K31/4523 , A61K31/453 , A61K31/4709 , C07D211/26 , C07D401/12 , C07D405/12
摘要： This invention relates to new inhibitors of butyrylcholinesterase with general formulas I and II, where substituents are described in patent description. Compounds can be in the form of pure enantiomers or as racemic mixtures, or in the form of pharmaceutically acceptable salts. The present invention relates to the use of these inhibitors for the treatment of Alzheimer's disease and other forms of dementia.
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公开(公告)号：EP3256128B1
公开(公告)日：2018-11-14
申请号：EP16720556.6
申请日：2016-03-22
申请人： Univerza v Ljubljani
发明人： BRUS, Boris , KOSAK, Urban , KNEZ, Damijan , COQUELLE, Nicolas , COLLETIER, Jacques-Philippe , GOBEC, Stanislav
IPC分类号： A61K31/445 , A61K31/4523 , A61K31/453 , A61K31/4709 , C07D311/10 , C07D215/26 , C07D277/42 , C07D295/04 , A61P25/28
CPC分类号： C07D211/28 , A61K31/445 , A61K31/4523 , A61K31/453 , A61K31/4709 , C07D211/26 , C07D401/12 , C07D405/12
摘要： This invention relates to new inhibitors of butyrylcholinesterase with general formulas I and II, where substituents are described in patent description. Compounds can be in the form of pure enantiomers or as racemic mixtures, or in the form of pharmaceutically acceptable salts. The present invention relates to the use of these inhibitors for the treatment of Alzheimer's disease and other forms of dementia.
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