公开(公告)号：EP2222690A2

公开(公告)日：2010-09-01

申请号：EP08801032.7

申请日：2008-08-20

申请人： Ustav Organicke Chemie A Biochemie Akademie Ved Ceske Republiky ,  Univerzita palackeho V Olomouci

发明人： OKLESTKOVA, Jana ,  HOFFMANNOVÁ, Lucie ,  STEIGEROVÁ,, Jana ,  KOHOUT, Ladislav ,  KOLAR, Zdenek ,  STRNAD, Miroslav

IPC分类号： C07J73/00 ,  A61K31/575 ,  A61K31/58 ,  C07D313/10 ,  C07J9/00 ,  C07J17/00 ,  A61P35/04

CPC分类号： C07J17/005 ,  C07D313/06 ,  C07D313/10 ,  C07J9/00 ,  C07J73/00

摘要： The present invention relates to natural brassinosteroids of general formula (I), wherein R is CH2 or O-CH2 group, R2 is hydrogen or hydroxyl, R3 is hydroxyl, R24 is alkyl or alkenyl, which are selected from the group consisting of methyl, ethyl, propyl, isopropyl, methylen, ethylen and propylen, and R25 is alkyl selected from the group consisting of methyl and ethyl, and a pharmaceutically acceptable salt thereof, for use for treating hyperproliferation, treating proliferative diseases and reducing adverse effects of steroid dysfunction in mammals. The present invention also provides methods capable to arrest of the cell cycle by natural brassinosteroids resulting in apoptotic changes in cancer cells. More specifically, the present invention relates to use for treatment of the adverse effects of hyperproliferation on mammalian cells in vitro and in vivo, especially treatment of hyperproliferative diseases in mammals by administering compositions containing natural brassinosteroids. This invention also describes new use for treating consisting in a new therapeutic way for modifying cell viability of human breast and prostate cancer cells.