利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

2 条记录 (耗时 0.015 秒)

    Lipophosphonoxins, method of their preparation and use
    2.
    发明公开
    Lipophosphonoxins, method of their preparation and use 有权
    Lipophosphonoxine，Verfahren zur Herstellung und Verwendung

    公开(公告)号：EP2527351A1

    公开(公告)日：2012-11-28

    申请号：EP12169491.3

    申请日：2012-05-25

    申请人： Ustav Organicke Chemie A Biochemie Av Cr, V.v.i. ,  Mikrobiologicky Ustav AV CR V.V.I. ,  Ustav Molekularni Genetiky Av Cr, V.v.i. ,  Trios, spol. s r.o.

    发明人： Rejman, Dominik ,  Pohl, Radek ,  Bartunek, Petr ,  Ribeiro Pombinho, Antonio Jose ,  Krasny, Libor ,  Latal, Tomas

    IPC分类号： C07F9/6558 ,  C07F9/6561 ,  A61K31/675 ,  A61P31/04

    CPC分类号： C07F9/6561 ,  C07F9/65586

    摘要： The invention discloses lipophosphonoxins of general formula I, wherein R 1 is (C 8 -C 22 )alkyl or hexadecyloxypropyl, tetradecyloxypropyl, tetradecyloxyethyl or hexadecyloxyethyl and R 2 is uracil, thymin or cytosin, R 3 is selected from group comprising compounds of general formula II and III, where R 4 is H or CH 2 OH, R 5 is H or OH, R 6 is H or OH, R 7 is H or CH 2 OH, R 8 is H or CH 2 OH, R 9 is H or OH, R 10 is H or OH, R 11 is H or OH, R 12 is H or CH 2 OH. Described are also diastereomers and mixtures of diastereomers of compounds of general formula I as well as corresponding pharmaceutically acceptable salts and hydrates and also a suitable method of preparation of such compounds. All described compounds of general formula I can be used as antibacterial agents or as active components of disinfectants and/or of selective in vitro growth media.

    摘要翻译： 本发明公开了通式Ⅰ的脂磷氧化还原剂，其中R 1为（C 8 -C 22）烷基或十六烷氧基丙基，十四烷氧基丙基，十四烷氧基乙基或十六烷氧基乙基，R 2为尿嘧啶，甲氨宁或细胞碱，R 3选自通式 II和III，其中R 4是H或CH 2 OH，R 5是H或OH，R 6是H或OH，R 7是H或CH 2 OH，R 8是H或CH 2 OH，R 9是H 或OH，R 10为H或OH，R 11为H或OH，R 12为H或CH 2 OH。 还描述了通式I化合物的非对映异构体和非对映异构体的混合物，以及相应的药学上可接受的盐和水合物，以及这些化合物的合适的制备方法。 所有描述的通式I化合物可用作抗菌剂或作为消毒剂和/或选择性体外生长培养基的活性成分。