专利检索 ap:("Ustav organicke chemie a biochemie AV CR, v.v.i." OR "Masarykova Univerzita" OR "FAKULTNI NEMOCNICE U SV. ANNY V BRNE") AND inv:"Cigler, Petr" 第 1 页

1.

发明公开
NANODIAMONDS AS ARTIFICIAL PROTEINS FOR REGULATION OF A CELL SIGNALLING SYSTEM 审中-公开

公开(公告)号：EP3545962A1

公开(公告)日：2019-10-02

申请号：EP18165299.1

申请日：2018-03-30

申请人： Ustav organicke chemie a biochemie AV CR, v.v.i. , Masarykova Univerzita , FAKULTNI NEMOCNICE U SV. ANNY V BRNE

发明人： Cigler, Petr , Balek, Lukas , Havlik, Jan , Krejci, Pavel , Trantirek, Lukas , Trantirkova, Silvie

IPC分类号： A61K33/44 , A61P35/00 , A61K9/14

摘要： The invention provides nanodiamonds having a positive ζ-potential of at least 1 mV for use in sequestration of at least one FGF family member in organisms in vivo and in vitro. It has been found that nanodiamonds with a positive ζ-potential show an extremely strong and selective binding to FGF family members, thus leading to their usability in the treatment of diseases related to aberrant FGF-FGFR signalling and/or interaction.