专利检索 ap:("Ustav organicke chemie a biochemie AV CR, v.v.i." OR "Vyzkumny Ustav Veterinarniho lékarstvi, v.v.i.") AND inv:"DRASAR, Lukas" 第 1 页

1.

发明授权
LIPOPOLYAMINES OF SPERMINE TYPE FOR CONSTRUCTION OF LIPOSOMAL TRANSFECTION SYSTEMS 有权
标题翻译： LIPOPOLYAMINE VOM SPERMIN-TYP ZUR KONSTRUKTION VON LIPOSOMALEN TRANSFEKTIONSSYSTEMEN

公开(公告)号：EP2802556B1

公开(公告)日：2017-01-04

申请号：EP13704708.0

申请日：2013-01-14

申请人： Ustav organicke chemie a biochemie AV CR, v.v.i. , Vyzkumny Ustav Veterinarniho lékarstvi, v.v.i.

发明人： DRASAR, Lukas , LEDVINA, Miroslav , KORVASOVA, Zina , TURANEK, Jaroslav

IPC分类号： C07C233/18 , C07C233/35 , C07J9/00 , C07J41/00 , A61K9/127 , A61K47/18 , C12N15/88

CPC分类号： A61K9/1272 , A61K47/18 , C07C233/18 , C07C233/35 , C07J9/00 , C07J41/0055 , C12N15/88

2.

发明公开
LIPOPOLYAMINES OF SPERMINE TYPE FOR CONSTRUCTION OF LIPOSOMAL TRANSFECTION SYSTEMS 有权
标题翻译：从脂多胺精胺TYPE，建设脂质体转染

公开(公告)号：EP2802556A1

公开(公告)日：2014-11-19

申请号：EP13704708.0

申请日：2013-01-14

申请人： Ustav organicke chemie a biochemie AV CR, v.v.i. , Vyzkumny Ustav Veterinarniho lékarstvi, v.v.i.

发明人： DRASAR, Lukas , LEDVINA, Miroslav , KORVASOVA, Zina , TURANEK, Jaroslav

IPC分类号： C07C233/18 , C07C233/35 , C07J41/00 , A61K9/127

CPC分类号： A61K9/1272 , A61K47/18 , C07C233/18 , C07C233/35 , C07J9/00 , C07J41/0055 , C12N15/88

摘要： The invention provides new lipopolyamines of spermine type of the general formula I, wherein X is C-N bond or aminopolyethyleneglycolcarboxamide linker or o-hydroxy- alkylcarboxamide linker or ω-hydroxyalkylcarboxamidopolyethyleneglycol- carboxamide linker, and wherein a hydrophobic domain Y is an acyl symmetrically branched in the position C(2) or cholesteryl. The invention further provides a method of preparation of said lipopolyamines and their use for construction of polycationic liposomal drug carriers.