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    SELF-ASSEMBLING MODULAR PERCUTANEOUS VALVE
    1.
    发明公开
    SELF-ASSEMBLING MODULAR PERCUTANEOUS VALVE 审中-公开
    自组装模块化的经皮瓣膜

    公开(公告)号：EP3178445A1

    公开(公告)日：2017-06-14

    申请号：EP17153292.2

    申请日：2010-01-13

    申请人： VALVE MEDICAL LTD.

    发明人： RICHTER, Yoram ,  RICHTER, Jacob ,  WEISZ, Ety

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2415 ,  A61F2/24 ,  A61F2/2406 ,  A61F2/2409 ,  A61F2/2412 ,  A61F2/2418 ,  A61F2/2427 ,  A61F2/844 ,  A61F2210/0014 ,  A61F2230/0091 ,  A61F2250/006

    摘要： The present invention provides a modular prosthetic valve device designed as two or more device modules that may be delivered to a body lumen unassembled and then assembled into the assembled valve device in the body at least in part using a self-assembly member at or near the site of valve implantation. The device modules may include a support structure and a valve module. The valve module may be delivered in an unassembled, folded delivery configuration, and unfolded and assembled into a working configuration via the self-assembly member. In its unassembled form, the valve module may be a single-piece leaflets substructure or a plurality of valve sections. The self-assembly member has a delivery configuration and a preset configuration, and may be triggered to revert to the preset configuration to assemble the valve module. The modular valve device may be folded in a manner not possible with current valve devices, for example, by rolling the unassembled valve module along its circumferential axis in the direction of its height, so that the diameter of the folded valve module may be equivalent to that of one rolled leaflet. This feature of the invention provides a percutaneous valve device having a smaller delivery diameter than pre-assembled valve devices. This in turn permits use of a delivery device of reduced diameter and increases the flexibility of the loaded delivery device compared to percutaneous valve devices in the art. The invention further provides a system for and method of folding and delivering such a modular valve device and assembling it using the self-assembly member, preferably in the body.

    摘要翻译： 本发明提供了一种模块化假体瓣膜装置，其被设计为两个或更多个装置模块，所述装置模块可被输送到未组装的体腔，然后至少部分地使用位于或靠近 瓣膜植入部位。 装置模块可以包括支撑结构和阀模块。 阀模块可以以未组装，折叠的输送构造输送，并且通过自组装构件展开并组装成工作构型。 在其未组装形式中，阀模块可以是单件小叶子结构或多个阀部分。 自组装构件具有递送配置和预设配置，并且可被触发以恢复到预设配置以组装阀模块。 模块化阀装置可以用当前的阀装置不可能的方式折叠，例如通过沿其高度方向将未组装的阀模块沿其周向轴线滚动，使得折叠的阀模块的直径可以等于 一张滚动的传单。 本发明的这个特征提供了一种经皮瓣膜装置，其具有比预先组装的瓣膜装置更小的输送直径。 这又允许使用与本领域中的经皮瓣膜装置相比直径减小的递送装置并增加装载的递送装置的灵活性。 本发明进一步提供了一种用于折叠和输送这种模块化阀装置并使用自组装元件将其组装的系统和方法，所述自组装元件优选在体内。

    SELF-ASSEMBLING MODULAR PERCUTANEOUS VALVE AND METHODS OF FOLDING, ASSEMBLY AND DELIVERY
    4.
    发明公开
    SELF-ASSEMBLING MODULAR PERCUTANEOUS VALVE AND METHODS OF FOLDING, ASSEMBLY AND DELIVERY 审中-公开
    自组装模块化经皮瓣膜及折叠，组装和递送方法

    公开(公告)号：EP3111890A3

    公开(公告)日：2017-02-08

    申请号：EP16183064.1

    申请日：2010-01-13

    申请人： VALVE MEDICAL LTD.

    发明人： RICHTER, Yoram ,  RICHTER, Jacob ,  WEISZ, Ety

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2415 ,  A61F2/24 ,  A61F2/2406 ,  A61F2/2409 ,  A61F2/2412 ,  A61F2/2418 ,  A61F2/2427 ,  A61F2/844 ,  A61F2210/0014 ,  A61F2230/0091 ,  A61F2250/006

    摘要： The present invention provides a modular prosthetic valve device designed as two or more device modules that may be delivered to a body lumen unassembled and then assembled into the assembled valve device in the body at least in part using a self-assembly member at or near the site of valve implantation. The device modules may include a support structure and a valve module. The valve module may be delivered in an unassembled, folded delivery configuration, and unfolded and assembled into a working configuration via the self-assembly member. In its unassembled form, the valve module may be a single-piece leaflets substructure or a plurality of valve sections. The self-assembly member has a delivery configuration and a preset configuration, and may be triggered to revert to the preset configuration to assemble the valve module. The modular valve device may be folded in a manner not possible with current valve devices, for example, by rolling the unassembled valve module along its circumferential axis in the direction of its height, so that the diameter of the folded valve module may be equivalent to that of one rolled leaflet. This feature of the invention provides a percutaneous valve device having a smaller delivery diameter than pre-assembled valve devices. This in turn permits use of a delivery device of reduced diameter and increases the flexibility of the loaded delivery device compared to percutaneous valve devices in the art. The invention further provides a system for and method of folding and delivering such a modular valve device and assembling it using the self-assembly member, preferably in the body.

    摘要翻译： 本发明提供了一种模块化假体瓣膜装置，其被设计为两个或更多个装置模块，所述装置模块可被输送到未组装的体腔，然后至少部分地使用位于或靠近 瓣膜植入部位。 装置模块可以包括支撑结构和阀模块。 阀模块可以以未组装，折叠的输送构造输送，并且通过自组装构件展开并组装成工作构型。 在其未组装形式中，阀模块可以是单件小叶子结构或多个阀部分。 自组装构件具有递送配置和预设配置，并且可被触发以恢复到预设配置以组装阀模块。 模块化阀装置可以用当前的阀装置不可能的方式折叠，例如通过沿其高度方向将未组装的阀模块沿其周向轴线滚动，使得折叠的阀模块的直径可以等于 一张滚动的传单。 本发明的这个特征提供了一种经皮瓣膜装置，其具有比预先组装的瓣膜装置更小的输送直径。 这又允许使用与本领域中的经皮瓣膜装置相比直径减小的递送装置并增加装载的递送装置的灵活性。 本发明进一步提供了一种用于折叠和输送这种模块化阀装置并使用自组装元件将其组装的系统和方法，所述自组装元件优选在体内。

    SELF-ASSEMBLING MODULAR PERCUTANEOUS VALVE AND METHODS OF FOLDING, ASSEMBLY AND DELIVERY
    5.
    发明公开
    SELF-ASSEMBLING MODULAR PERCUTANEOUS VALVE AND METHODS OF FOLDING, ASSEMBLY AND DELIVERY 审中-公开

    公开(公告)号：EP3111890A2

    公开(公告)日：2017-01-04

    申请号：EP16183064.1

    申请日：2010-01-13

    申请人： VALVE MEDICAL LTD.

    发明人： RICHTER, Yoram ,  RICHTER, Jacob ,  WEISZ, Ety

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2415 ,  A61F2/24 ,  A61F2/2406 ,  A61F2/2409 ,  A61F2/2412 ,  A61F2/2418 ,  A61F2/2427 ,  A61F2/844 ,  A61F2210/0014 ,  A61F2230/0091 ,  A61F2250/006

    摘要： The present invention provides a modular prosthetic valve device designed as two or more device modules that may be delivered to a body lumen unassembled and then assembled into the assembled valve device in the body at least in part using a self-assembly member at or near the site of valve implantation. The device modules may include a support structure and a valve module. The valve module may be delivered in an unassembled, folded delivery configuration, and unfolded and assembled into a working configuration via the self-assembly member. In its unassembled form, the valve module may be a single-piece leaflets substructure or a plurality of valve sections. The self-assembly member has a delivery configuration and a preset configuration, and may be triggered to revert to the preset configuration to assemble the valve module. The modular valve device may be folded in a manner not possible with current valve devices, for example, by rolling the unassembled valve module along its circumferential axis in the direction of its height, so that the diameter of the folded valve module may be equivalent to that of one rolled leaflet. This feature of the invention provides a percutaneous valve device having a smaller delivery diameter than pre-assembled valve devices. This in turn permits use of a delivery device of reduced diameter and increases the flexibility of the loaded delivery device compared to percutaneous valve devices in the art. The invention further provides a system for and method of folding and delivering such a modular valve device and assembling it using the self-assembly member, preferably in the body.

    APPARATUS FOR FINE ADJUSTMENT OF A PERCUTANEOUS VALVE STRUCTURE
    9.
    发明授权
    APPARATUS FOR FINE ADJUSTMENT OF A PERCUTANEOUS VALVE STRUCTURE 有权
    精密调整经皮瓣膜结构的装置

    公开(公告)号：EP2379010B2

    公开(公告)日：2018-04-04

    申请号：EP10702540.5

    申请日：2010-01-13

    申请人： VALVE MEDICAL LTD.

    发明人： RICHTER, Yoram ,  RICHTER, Jacob ,  WEISZ, Ety

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2418 ,  A61F2/2409 ,  A61F2/2427 ,  A61F2230/0013 ,  A61F2250/0006 ,  A61F2250/0008 ,  A61F2250/006

    摘要： The invention provides a device for fine adjustment of a prosthetic valve device and a method of adjusting the position of a prosthetic valve after implantation. The adjustment mechanism includes complementary structures on a valve member and device frame that cooperate to provide relative axial and/or angular motion between the valve member and device frame (and thus the native vessel). The adjustment mechanism of the invention may also include a means for selectively maintaining the relative position of the valve member and device frame. The device and method are particularly applicable for use with a modular prosthetic valve device that is assembled in the body lumen.

    TEMPORARY VALVE AND VALVE-FILTER
    10.
    发明公开
    TEMPORARY VALVE AND VALVE-FILTER 审中-公开
    临时的，啪啪啪啪FILTER

    公开(公告)号：EP2967807A2

    公开(公告)日：2016-01-20

    申请号：EP14766197.9

    申请日：2014-03-13

    申请人： VALVE MEDICAL LTD.

    发明人： RICHTER, Yoram ,  WEISZ, Ety ,  SCHWARZ, Boaz

    IPC分类号： A61F2/01 ,  A61F2/24

    摘要： A temporary percutaneous valve-filter device having valve portions non-porous to blood and filter portions non-porous to emboli but at least in part porous to blood. In one embodiment, the device has a substantially flat valve unit and a substantially flat filter unit. In another embodiment, the device has at least one open umbrella deployed configuration. In one aspect, the device has a unitary construction with one umbrella canopy with one or more filter areas with flaps allowing unidirectional blood flow. In another aspect, the device has a valve unit and filter unit, the umbrella canopies oriented in opposite directions, and the valve unit “closes” and opens to allow blood to flow to one direction. Also provided is a temporary valve system, including a core having an inverted delivery configuration and everted deployed configuration, that may be used with or without a filter unit, and a method of deployment.