专利检索 ap:("VERTEX PHARMA") AND inv:"BOYD MICHAEL JOHN" 第 1 页

1.

发明公开
INHIBITORS OF INFLUENZA VIRUSES REPLICATION 审中-公开

公开(公告)号：EP3294735A1

公开(公告)日：2018-03-21

申请号：EP16725672

申请日：2016-05-11

申请人： VERTEX PHARMA

发明人： FARMER LUC J , BOYD MICHAEL JOHN , SHANNON DEAN , WALDO MICHAEL , NTI ADDAE KWARNE W , ZHANG YUEGANG

IPC分类号： C07D471/04 , A61K31/506 , A61P31/16

CPC分类号： C07D471/04 , A61K31/4965 , A61K31/506 , A61K45/06 , C07B2200/13

摘要： include Hydrate 2 of Compound (1), Hydrate 3 of Compound (1), Form A of Compound (1), Form B of Compound (1), Form C of Compound (1), Form D of Compound (1), and amorphous Compound (1). Such polymorphic forms are useful for treating influenza, inhibiting the replication of influenza viruses, or reducing the amount of influenza viruses in a biological sample or in a subject.

2.

发明公开
METHODS OF PREPARING INHIBITORS OF INFLUENZA VIRUSES REPLICATION 审中-公开

公开(公告)号：EP3294717A1

公开(公告)日：2018-03-21

申请号：EP16725308

申请日：2016-05-11

申请人： VERTEX PHARMA

发明人： FARMER LUC J , BOYD MICHAEL JOHN , MILLER DAVID B JR , CWYNAR VALERIE ANN

IPC分类号： C07D239/42 , C07D471/04

CPC分类号： C07D471/04 , C07D239/42

摘要： in the presence of water, an organic solvent, a base, and a transition metal catalyst to generate a compound of Formula (I) or a pharmaceutically acceptable salt thereof.