公开(公告)号：EP1678145A2

公开(公告)日：2006-07-12

申请号：EP04796881.3

申请日：2004-10-28

申请人： VERTEX PHARMACEUTICALS INCORPORATED

发明人： WILSON, Dean, M. ,  TERMIN, Andreas, P. ,  GONZALEZ, Jesus, E. III ,  ZIMMERMANN, Nicole ,  ZHANG, Yulian ,  FANNING, Lev, T. D.

IPC分类号： C07D235/18 ,  C07D401/04 ,  C07D403/04 ,  C07D209/14 ,  A61K31/415 ,  A61K31/33

CPC分类号： C07D405/12 ,  C04B35/632 ,  C07D209/42 ,  C07D235/14 ,  C07D235/18 ,  C07D401/04 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D409/12 ,  C07D413/12

摘要： The present invention relates to compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein the R1, Z, Y, RA, and W groups of formula I are as defined herein. The invention also provides pharmaceutically acceptable compositions and methods of suing the compositions in the treatment of various disorders.