公开(公告)号：EP1608632B1

公开(公告)日：2009-12-30

申请号：EP04716887.7

申请日：2004-03-03

申请人： VERTEX PHARMACEUTICALS INCORPORATED

发明人： GONZALES, Jesus, E., III ,  WILSON, Dean, Mitchell ,  TERMIN, Andreas, Peter ,  GROOTENHUIS, Peter, Diederik, Jan ,  ZHANG, Yulian ,  PETZOLDT, Benjamin, John ,  FANNING, Lev, Tyler, Dewey ,  NEUBERT, Timothy, Donald ,  TUNG, Roger, D. ,  MARTINBOROUGH, Esther ,  ZIMMERMANN, Nicole

IPC分类号： C07D239/94 ,  C07D403/04 ,  C07D413/12 ,  A61K31/517 ,  C07D401/12 ,  C07D401/04 ,  C07D403/12 ,  C07D401/14 ,  C07D405/12 ,  C07D403/14 ,  C07D417/12 ,  C07D409/14 ,  C07D417/14 ,  C07D409/12 ,  C07D471/04

CPC分类号： C07D239/94 ,  C07D239/91 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/04 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04

摘要： The present invention relates to quinazoline compounds of formula (I) useful as inhibitors of voltage-gated sodium channels and calcium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders. or a pharmaceutically acceptable derivative thereof, wherein R1, X, R3, x, and ring A are as defined in the present application.

公开(公告)号：EP1608632A1

公开(公告)日：2005-12-28

申请号：EP04716887.7

申请日：2004-03-03

申请人： VERTEX PHARMACEUTICALS INCORPORATED

发明人： GONZALES, Jesus, E., III ,  WILSON, Dean, Mitchell ,  TERMIN, Andreas, Peter ,  GROOTENHUIS, Peter, Diederik, Jan ,  ZHANG, Yulian ,  PETZOLDT, Benjamin, John ,  FANNING, Lev, Tyler, Dewey ,  NEUBERT, Timothy, Donald ,  TUNG, Roger, D. ,  MARTINBOROUGH, Esther ,  ZIMMERMANN, Nicole

IPC分类号： C07D239/94 ,  C07D403/04 ,  C07D413/12 ,  A61K31/517 ,  C07D401/12 ,  C07D401/04 ,  C07D403/12 ,  C07D401/14 ,  C07D405/12 ,  C07D403/14 ,  C07D417/12 ,  C07D409/14 ,  C07D417/14 ,  C07D409/12 ,  C07D471/04

CPC分类号： C07D239/94 ,  C07D239/91 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/04 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04

摘要： The present invention relates to quinazoline compounds of formula (I) useful as inhibitors of voltage-gated sodium channels and calcium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders. or a pharmaceutically acceptable derivative thereof, wherein R1, X, R3, x, and ring A are as defined in the present application.