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公开(公告)号:EP3022230A1
公开(公告)日:2016-05-25
申请号:EP14734166.3
申请日:2014-07-01
申请人: VIB VZW , Universiteit Gent , Centre National de la Recherche Scientifique , Université Montpellier 2 , Centre Hospitalier Regional Universitaire De Montpellier
发明人: TAVERNIER, Jan , ZABEAU, Lennart , UZÉ, Gilles , PAUL, Franciane , BORDAT, Yann , GARCIN, Geneviève
摘要: The present invention relates to a fusion protein, comprising a cytokine antagonist and a targeting moiety, preferably an antibody or anti-body like molecule. In a preferred embodiment, the cytokine antagonist is a modified cytokine which binds to the receptor, but doesn't induce the receptor signalling. The invention relates further to a fusion protein according to the invention for use in treatment of cancer and immune- or inflammation-related disorders.
摘要翻译: 本发明涉及融合蛋白,其包含细胞因子拮抗剂和靶向部分,优选抗体或抗体样分子。 在优选的实施方案中,细胞因子拮抗剂是与受体结合但不诱导受体信号传导的修饰的细胞因子。 本发明进一步涉及根据本发明的用于治疗癌症和免疫或炎症相关疾病的融合蛋白。
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公开(公告)号:EP3022230B1
公开(公告)日:2019-11-06
申请号:EP14734166.3
申请日:2014-07-01
申请人: VIB VZW , Universiteit Gent , Centre National de la Recherche Scientifique , Université de Montpellier , Centre Hospitalier Régional Universitaire de Montpellier
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公开(公告)号:EP3580230A1
公开(公告)日:2019-12-18
申请号:EP18708337.3
申请日:2018-02-06
申请人: VIB vzw , Universiteit Gent , Centre National de la Recherche Scientifique , Université Montpellier
IPC分类号: C07K14/435 , A61K38/20 , C07K14/56 , C07K19/00
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