公开(公告)号：EP1337242A2

公开(公告)日：2003-08-27

申请号：EP01999202.3

申请日：2001-10-19

申请人： Valentis, Inc.

发明人： COLEMAN, Michael, E. ,  MACLAUGHLIN, Fiona ,  WANG, Jijun ,  THIESSE, Mary, L. ,  YOUNG, Stewart ,  NORDSTROM, Jeffrey, L.

IPC分类号： A61K9/14 ,  A61K48/00 ,  C12N15/63

CPC分类号： C12N15/87 ,  A61K38/1866 ,  A61K48/00 ,  A61K48/0008 ,  A61K48/0075 ,  C07K14/475

摘要： The present inventors have developed a novel approach for efficient delivery of angiogenic factors to the cardiac and peripheral vasculature that avoids problems with toxicity inherent to existing delivery technologies. Vectors carrying coding sequences for Del-1 or VEGF, or both, can be formulated with poloxamers or other polymers for delivery into ischemic tissue and delivered to the heart by retrograde venous perfusion.