专利检索 ap:("Vanderbilt University") AND inv:"ALCAZAR VACA, Manuel, Jesus" 第 1 页

1.

发明公开
BICYCLIC OXAZOLE AND THIAZOLE COMPOUNDS AND THEIR USE AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS 审中-公开
标题翻译：双环恶唑和噻唑化合物及其作为代谢型谷氨酸受体的变构调节剂5个受体使用

公开(公告)号：EP2611298A1

公开(公告)日：2013-07-10

申请号：EP11822606.7

申请日：2011-08-31

申请人： Vanderbilt University

发明人： CONN, P., Jeffrey , LINDSLEY, Craig, W. , STAUFFER, Shaun, R. , JONES, Carrie, K. , BARTOLOME-NEBREDA, Jose, Manuel , CONDE-CEIDE, Susana , MACDONALD, Gregor, James , ALCAZAR VACA, Manuel, Jesus

IPC分类号： A01N43/76 , A61K31/42

CPC分类号： C07D513/04 , C07D498/04

摘要： In one aspect, the invention relates to novel bicyclic oxazole and thiazole compounds which are positive allosteric modulators of the metabotropic glutamate receptor subtype 5 ("mGluR5"); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions; and methods for the treatment or prevention of disorders associated with glutamate dysfunction and diseases in which the mGluR5 subtype of receptors is involved. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.