公开(公告)号：EP3509613A1

公开(公告)日：2019-07-17

申请号：EP17849559.4

申请日：2017-09-07

申请人： Vanderbilt University

发明人： CHEUNG-FLYNN, Joyce ,  BROPHY, Colleen, M.

IPC分类号： A61K38/00 ,  C07K7/00 ,  A61K38/04

公开(公告)号：EP2509609B1

公开(公告)日：2014-10-01

申请号：EP10807761.1

申请日：2010-12-08

申请人： Vanderbilt University ,  The United States Government as Represented by the Department of Veterans Affairs

发明人： BROPHY, Colleen ,  KOMALAVILAS, Padmini ,  CHEUNG-FLYNN, Joyce ,  HOCKING, Kyle ,  EAGLE, Susan

IPC分类号： A61K35/44 ,  A61K31/185 ,  A61M39/06

CPC分类号： A01N1/0226 ,  A01N1/0247 ,  A01N1/0278 ,  A61K31/185 ,  A61K35/44 ,  A61M39/06

摘要： The leading cause of graft failure is the subsequent development of intimal hyperplasia, which represents a response to injury that is thought to involve smooth muscle proliferation, migration, phenotypic modulation, and extracellular matrix (ECM) deposition. Surgical techniques typically employed for vein harvest - stretching the vein, placing the vein in low pH, solutions, and the use of toxic surgical skin markers - are shown here to cause injury. The invention therefore provides for non-toxic surgical markers than also protect against stretch-induced loss of functional viability, along with other additives. Devices and compositions for reducing physical stress or protecting from the effects flowing therefrom, also are provided.

公开(公告)号：EP2509609A2

公开(公告)日：2012-10-17

申请号：EP10807761.1

申请日：2010-12-08

申请人： Vanderbilt University ,  The United States Government as represented by Department of Veteran's Affairs

发明人： BROPHY, Colleen ,  KOMALAVILAS, Padmini ,  CHEUNG-FLYNN, Joyce ,  HOCKING, Kyle ,  EAGLE, Susan

IPC分类号： A61K35/44 ,  A61K31/185 ,  A61M39/06

CPC分类号： A01N1/0226 ,  A01N1/0247 ,  A01N1/0278 ,  A61K31/185 ,  A61K35/44 ,  A61M39/06

摘要： The leading cause of graft failure is the subsequent development of intimal hyperplasia, which represents a response to injury that is thought to involve smooth muscle proliferation, migration, phenotypic modulation, and extracellular matrix (ECM) deposition. Surgical techniques typically employed for vein harvest - stretching the vein, placing the vein in low pH, solutions, and the use of toxic surgical skin markers - are shown here to cause injury. The invention therefore provides for non-toxic surgical markers than also protect against stretch-induced loss of functional viability, along with other additives. Devices and compositions for reducing physical stress or protecting from the effects flowing therefrom, also are provided.

摘要翻译： 移植物衰竭的主要原因是内膜增生的随后发展，其代表对被认为涉及平滑肌增生，迁移，表型调节和细胞外基质（ECM）沉积的损伤的反应。 通常用于静脉收获的手术技术 - 拉伸静脉，将静脉置于低pH值，溶液和使用毒性手术皮肤标记物 - 这里显示为造成损伤。 因此，本发明提供无毒手术标记物，同时也防止拉伸诱导的功能活力丧失以及其它添加剂。 还提供了用于减少物理应力或防止其从其流出的影响的装置和组合物。