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1.发明公开SUBSTITUTED BENZAMIDE ANALOGS AS MGLUR5 NEGATIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING THE SAME 审中-公开取代BENZAMIDANALOGA负变构mGluR5调节剂和方法的生产和使用
公开(公告)号：EP2477630A1
公开(公告)日：2012-07-25
申请号：EP10817950.8
申请日：2010-09-17
发明人： CONN, P., Jeffrey , LINDSLEY, Craig, W. , EMMITTE, Kyle, A. , WEAVER, Charles, David , RODRIGUEZ, Alice, L. , FELTS, Andrew, S. , JONES, Carrie, K. , BATES, Brittney, S.
IPC分类号： A61K31/535
CPC分类号： A61K31/4406 , A61K31/497 , C07D401/12 , C07D401/14
摘要： Disclosed are negative allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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2.发明公开SUBSTITUTED HETEROARYLAMIDE ANALOGS AS MGLUR5 NEGATIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING THE SAME 有权取代HETEROARYLAMIDANALOGE负的mGluR5变构调节剂，和方法的生产和使用
公开(公告)号：EP2477629A1
公开(公告)日：2012-07-25
申请号：EP10817936.7
申请日：2010-09-17
发明人： CONN, P., Jeffrey , LINDSLEY, Craig, W. , EMMITTE, Kyle, A. , WEAVER, Charles, David , RODRIGUEZ, Alice, L. , FELTS, Andrew, S. , JONES, Carrie, K. , BATES, Brittney, S.
IPC分类号： A61K31/535
CPC分类号： A61K31/4406 , A61K31/497 , C07D401/12 , C07D401/14
摘要： Disclosed are negative allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention
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3.发明授权SUBSTITUTED HETEROARYLAMIDE ANALOGS AS MGLUR5 NEGATIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING THE SAME 有权取代HETEROARYLAMIDANALOGE负的mGluR5变构调节剂，和方法的生产和使用
公开(公告)号：EP2477629B1
公开(公告)日：2016-08-03
申请号：EP10817936.7
申请日：2010-09-17
发明人： CONN, Jeffrey, P. , LINDSLEY, Craig, W. , EMMITTE, Kyle, A. , WEAVER, Charles, David , RODRIGUEZ, Alice, L. , FELTS, Andrew, S. , JONES, Carrie, K. , BATES, Brittney, S.
IPC分类号： A61K31/535 , A61K31/4406 , A61K31/497 , C07D401/12 , C07D401/14 , A61P25/00
CPC分类号： A61K31/4406 , A61K31/497 , C07D401/12 , C07D401/14
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4.发明公开6-ALKYL-N-(PYRIDIN-2-YL)-4-ARYLOXYPICOLINAMIDE ANALOGS AS MGLUR5 NEGATIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING THE SAME 审中-公开1-6 - 烷基-N-（吡啶-2-基）-4- aryloxypicolinamide类似物作为阴性的mGluR5变构调节剂及其制备方法和使用
公开(公告)号：EP2680849A2
公开(公告)日：2014-01-08
申请号：EP12752374.4
申请日：2012-03-05
发明人： CONN, P., Jeffrey , LINDSLEY, Craig, W. , EMMITTE, Kyle, A. , RODRIGUEZ, Alice, L. , FELTS, Andrew, S. , JONES, Carrie, K. , BATES, Brittney, S. , CHAUDER, Brian, A.
IPC分类号： A61K31/513 , C07D401/14
CPC分类号： C07D401/14 , A61K31/513 , C07D213/81 , C07D401/12
摘要： Disclosed are negative allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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5.发明公开SUBSTITUTED PHENYLAMINE CARBOXAMIDE ANALOGS AS MGLUR5 NEGATIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING THE SAME 审中-公开取代的苯胺甲酰胺类似物负变构mGluR5调节剂和方法的生产和使用
公开(公告)号：EP2477631A1
公开(公告)日：2012-07-25
申请号：EP10817954.0
申请日：2010-09-17
IPC分类号： A61K31/535
CPC分类号： A61K31/4406 , A61K31/497 , C07D401/12 , C07D401/14
摘要： Disclosed are negative allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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