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公开(公告)号：EP3765460A1
公开(公告)日：2021-01-20
申请号：EP19714008.0
申请日：2019-03-14
发明人： HOPKINS, Corey R. , RITTER, Matthew , HONG, Charles C. , LINDSLEY, Craig W. , VADUKOOT, Anish , ENGERS, Darren
IPC分类号： C07D471/04 , A61P35/00 , A61K31/5025
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2.发明公开SUBSTITUTED 1,1,3,3-TETRAOXIDOBENZO[D][1,3,2]DITHIAZOLES AS MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION 审中-公开取代的1,1,3,3- TETRAOXIDOBENZO [D]。[1,3,2]二噻唑的变构增强剂mGluR4，组合物和用于治疗神经机能障碍方法
公开(公告)号：EP2393785A1
公开(公告)日：2011-12-14
申请号：EP10736412.7
申请日：2010-01-28
发明人： CONN, P. Jeffrey , LINDSLEY, Craig W. , HOPKINS, Corey R. , WEAVER, Charles David , NISWENDER, Colleen M. , GOGLIOTTI, Rocco D. , ENGERS, Darren W.
IPC分类号： C07D239/00 , C07D403/12
CPC分类号： C07D285/01 , C07D403/12 , C07D417/12 , C07D417/14
摘要： Compounds useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4) and methods of using the compounds.
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公开(公告)号：EP3639823A1
公开(公告)日：2020-04-22
申请号：EP19200395.2
申请日：2012-10-28
发明人： LINDSLEY, Craig W. , CONN, P. Jeffrey , WOOD, Michael R. , HOPKINS, Corey R. , MELANCON, Bruce J. , POSLUSNEY, Michael S. , ENGERS, Darren W.
IPC分类号： A61K31/435 , A61K31/4353 , A61P25/00 , C07D471/04 , C07D487/04 , C07D491/04 , C07D401/14 , C07D519/00
摘要： In one aspect, the invention relates to substituted 2-(4-heterocyclylbenzyl)isoindolin-1-one analogs compounds, derivatives thereof, and related compounds which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M 1 (mAChR M 1 ); synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions.
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公开(公告)号：EP3570843A1
公开(公告)日：2019-11-27
申请号：EP18714380.5
申请日：2018-01-18
IPC分类号： A61K31/5025 , A61P35/00 , C07D487/04 , C07D471/04
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公开(公告)号：EP3512834A1
公开(公告)日：2019-07-24
申请号：EP17851525.0
申请日：2017-09-14
IPC分类号： C07D277/62 , C07D471/04 , C07D487/04
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6.发明公开MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION 审中-公开MGLUR4变体增效剂，组合物和治疗神经功能障碍的方法
公开(公告)号：EP2473055A1
公开(公告)日：2012-07-11
申请号：EP10814634.1
申请日：2010-09-07
发明人： CONN, P. Jeffrey , LINDSLEY, Craig W. , HOPKINS, Corey R. , WEAVER, Charles David , NISWENDER, Colleen M. , ENGERS, Darren W. , CHEUNG, Yiu-Yin , GENTRY, Patrick R. , SALOVICH, James M. , GOGLIOTTI, Rocco D.
IPC分类号： A01N55/02
CPC分类号： C07D487/04 , C07D401/10 , C07D471/04 , C07D498/04 , C07D513/04
摘要： Compounds useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4) and use thereof.
摘要翻译： 可用作代谢型谷氨酸受体亚型4（mGluR4）的变构增效剂/正变构调节剂的化合物及其用途。
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7.发明公开SUBSTITUTED BENZOIMIDAZOLESULFONAMIDES AND SUBSTITUTED INDOLESULFONAMIDES AS MGLUR4 POTENTIATORS 审中-公开取代的苯并咪唑磺酰胺和取代的吲哚磺酰胺作为MGLUR4增效剂
公开(公告)号：EP2456310A1
公开(公告)日：2012-05-30
申请号：EP10802979.4
申请日：2010-07-23
发明人： CONN, P. Jeffrey , LINDSLEY, Craig W. , HOPKINS, Corey R. , WEAVER, Charles David , NISWENDER, Colleen M. , CHEUNG, Yiu-Yin
IPC分类号： A01N43/56 , A61K31/415
CPC分类号： A61K31/415 , A61K31/404 , A61K45/06 , C07D235/06 , C07D235/18 , C07D401/04 , C07D401/12 , C07D403/04 , C07D407/04 , C07D409/04 , C07D413/04 , C07D417/04 , A61K2300/00
摘要： Disclosed are substituted benzoimidazolesulfonamides and substituted indolesulfonamides as mGluR4 potentiators.
摘要翻译： 公开了取代的苯并咪唑磺酰胺和取代的吲哚磺酰胺作为mGluR4增效剂。
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