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公开(公告)号：EP3153167B1
公开(公告)日：2019-10-02
申请号：EP16185778.4
申请日：2012-10-28
发明人： LINDSLEY, Craig, W. , CONN, P., Jeffrey , WOOD, Michael, R. , HOPKINS, Corey, R. , MELANCON, Bruce, J. , POSLUSNEY, Michael, S. , ENGERS, Darren, W.
IPC分类号： A61K31/435 , A61K31/4353 , A61P25/00 , C07D471/04 , C07D487/04 , C07D491/04 , C07D401/14 , C07D519/00
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2.发明公开SUBSTITUTED 2-(4-HETEROCYCLYLBENZYL)ISOINDOLIN-1-ONE ANALOGS AS POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M1 审中-公开替代2-（4-杂环苄基）异吲哚-1-酮ANALOGA ALS阳性ALLOSTERISCHE MODULATOREN DES MUSKARINISCHEN乙酰胆碱酯酶M1
公开(公告)号：EP3153167A1
公开(公告)日：2017-04-12
申请号：EP16185778.4
申请日：2012-10-28
发明人： LINDSLEY, Craig, W. , CONN, P., Jeffrey , WOOD, Michael, R. , HOPKINS, Corey, R. , MELANCON, Bruce, J. , POSLUSNEY, Michael, S. , ENGERS, Darren, W.
IPC分类号： A61K31/435 , A61K31/4353 , A61P25/00 , C07D471/04 , C07D487/04 , C07D491/04 , C07D401/14 , C07D519/00
摘要： In one aspect, the invention relates to substituted 2-(4-heterocyclylbenzyl)isoindolin-1-one analogs compounds, derivatives thereof, and related compounds which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M 1 (mAChR M 1 ); synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions.
摘要翻译： 一方面，本发明涉及可用作毒蕈碱乙酰胆碱受体M 1（mAChR M 1）的正变构调节剂的取代的2-（4-杂环基苄基）异二氢吲哚-1-酮类似物化合物，其衍生物和相关化合物。 制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用该化合物和组合物治疗与毒蕈碱性乙酰胆碱受体功能障碍相关的神经和精神疾病的方法。
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3.发明授权SUBSTITUTED 2-(4-HETEROCYCLYLBENZYL)ISOINDOLIN-1-ONE ANALOGS AS POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M1 有权替代2-（4-羟基苄基苄基）异吲哚啉-1-对 - 阿拉伯糖酸盐阳性胰岛素调节蛋白酶抑制剂乙酰胆碱酯酶M1
公开(公告)号：EP2770997B1
公开(公告)日：2016-09-14
申请号：EP12843949.4
申请日：2012-10-28
发明人： LINDSLEY, Craig, W. , CONN, P., Jeffrey , WOOD, Michael, R. , HOPKINS, Corey, R. , MELANCON, Bruce, J. , POSLUSNEY, Michael, S. , ENGERS, Darren, W.
IPC分类号： A61K31/435 , A61K31/4353 , A61P25/00 , C07D471/04 , C07D487/04 , C07D491/04
CPC分类号： C07D471/04 , C07D275/06 , C07D401/10 , C07D401/14 , C07D403/10 , C07D405/10 , C07D417/10 , C07D487/04 , C07D519/00
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4.发明授权SUBSTITUTED 5-AMINOTHIENO[2,3-C]PYRIDAZINE-6-CARBOXAMIDE ANALOGS AS POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 有权取代的5-氨基噻吩并[2,3-C]哒嗪-6-羧酰胺类似物作为麦考酚酸乙酰胆碱受体M4的正性变构调节剂
公开(公告)号：EP2817295B1
公开(公告)日：2017-11-01
申请号：EP13751391.7
申请日：2013-02-23
发明人： LINDSLEY, Craig, W. , CONN, P., Jeffrey , WOOD, Michael, R. , MELANCON, Bruce, J. , TARR, James, C. , SALOVICH, James, M. , POSLUSNEY, Michael, S.
IPC分类号： C07D237/26 , C07D409/02 , A61K31/5025 , A61P25/28 , C07D495/04
CPC分类号： C07D495/04 , C07D237/26 , C07D409/04 , C07D519/00 , C07F7/1804
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5.发明公开SUBSTITUTED 2-(4-HETEROCYCLYLBENZYL)ISOINDOLIN-1-ONE ANALOGS AS POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M1 有权取代的2-（4-HETEROCYCLYLBENZYL）异吲哚啉-1-酮类似物作为毒蕈碱正变构乙酰胆碱受体M1的调节剂
公开(公告)号：EP2770997A1
公开(公告)日：2014-09-03
申请号：EP12843949.4
申请日：2012-10-28
发明人： LINDSLEY, Craig, W. , CONN, P., Jeffrey , WOOD, Michael, R. , HOPKINS, Corey, R. , MELANCON, Bruce, J. , POSLUSNEY, Michael, S. , ENGERS, Darren, W.
IPC分类号： A61K31/435 , A61K31/4353 , A61P25/00 , C07D471/04 , C07D487/04 , C07D491/04
CPC分类号： C07D471/04 , C07D275/06 , C07D401/10 , C07D401/14 , C07D403/10 , C07D405/10 , C07D417/10 , C07D487/04 , C07D519/00
摘要： In one aspect, the invention relates to substituted 2-(4-heterocyclylbenzyl)isoindolin- 1-one analogs compounds, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M
1 (mAChR M
1 ); synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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