公开(公告)号：EP2935313A1

公开(公告)日：2015-10-28

申请号：EP13814593.3

申请日：2013-12-20

申请人： Vaxin UK Limited

发明人： GEORGES, Bertrand Victor Gilbert ,  BROWN, Carlton Bradley

IPC分类号： C07K14/02 ,  A61K39/29 ,  C12N7/00 ,  A61K39/12 ,  A61P35/00

CPC分类号： A61K39/292 ,  A61K39/12 ,  A61K45/06 ,  A61K2039/55 ,  A61K2039/572 ,  A61K2039/58 ,  A61K2039/60 ,  A61K2039/70 ,  C07K14/005 ,  C12N7/00 ,  C12N2730/10122 ,  C12N2730/10134 ,  C12N2730/10171

摘要： A pharmaceutical composition comprising at least two peptides of from 15 to 60 amino acids in length, selected from peptides comprising a sequence of at least 15 contiguous amino acids of one of the sequences shown in SEQ ID NOs: 1 to 4 or of a sequence having at least 80% identity to one of the sequences shown in SEQ ID NOs: to 4, wherein each peptide comprises at least one CD8+ T-cell epitope and/or at least one CD4+ T-cell epitope and wherein each peptide elicits a response in peripheral blood mononuclear cells (PBMC) from at least one chronically infected HBV individual in an 10 in vitroassay.