公开(公告)号：EP1841785A2

公开(公告)日：2007-10-10

申请号：EP06718667.6

申请日：2006-01-19

申请人： Vaxinnate Corporation

发明人： POWELL, Thomas, J. ,  NAKAAR, Valerian ,  SONG, Langzhou ,  HULEATT, James, W. ,  MCDONALD, William, F. ,  HEWITT, Duane, D.

IPC分类号： C07K14/00

CPC分类号： A61K39/12 ,  A61K38/162 ,  A61K38/164 ,  A61K39/0258 ,  A61K39/0275 ,  A61K2039/6068 ,  C07K14/005 ,  C07K14/245 ,  C07K14/255 ,  C07K2319/00 ,  C12N7/00 ,  C12N2770/24022 ,  C12N2770/24122 ,  C12N2770/24134 ,  Y02A50/386 ,  Y02A50/388 ,  Y02A50/39 ,  Y02A50/394 ,  Y02A50/396

摘要： Compositions comprise at least a portion of an antigen and at least a portion of a flagellin that lacks a hinge region. Compositions, fusion proteins and polypeptides comprise at least a portion of at least one pathogen-associated molecular pattern and at least a portion of at least one viral protein. The viral protein of the compositions, fusion proteins and polypeptides of the invention are flaviviral proteins, including a West Nile flaviviral protein, a Dengue flaviviral protein, a Langat flaviviral protein, a Kunjin flaviviral protein, a Murray Valley encephalitis flaviviral protein, a Japanese encephalitis flaviviral protein, a Tick- borne encephalitis flaviviral protein, a Yellow fever flaviviral protein and a hepatitis C flaviviral protein. The compositions, fusion proteins and polypeptides are used to stimulate an immune response in a subject.