公开(公告)号：EP3271725A1

公开(公告)日：2018-01-24

申请号：EP16710722.6

申请日：2016-03-16

申请人： Ventana Medical Systems, Inc. ,  University of Washington

发明人： TRUE, Lawrence ,  TUBBS, Alisa ,  WANG, Yixin ,  NAGY, Alexandra ,  ZHU, Yifei ,  REBELO DO COUTO, Fernando Jose ,  LIAO, Zhiming ,  ROUDIER, Martine

IPC分类号： G01N33/574

CPC分类号： G01N33/57434 ,  G01N2333/723 ,  G01N2800/52

摘要： The present disclosure relates to materials and methods for evaluating prostate cancer using binding entities (such as antibodies) that bind to the N-terminus and the C-Terminus of androgen receptor. Prostate samples are histochemically labeled for the N-terminus and the C-Terminus of androgen receptor, and a ratio between the binding of the N- and C-terminal antibodies is determined.

公开(公告)号：EP2531569B1

公开(公告)日：2017-01-25

申请号：EP11703788.7

申请日：2011-02-01

申请人： Ventana Medical Systems, Inc.

发明人： MAY, Eric ,  NAGY, Alexandra ,  KOSMEDER, Jerome

IPC分类号： C09K11/02 ,  G01N33/533 ,  G01N33/58 ,  B82Y15/00

CPC分类号： C09K11/025 ,  B82Y15/00 ,  C09K11/883 ,  G01N33/533 ,  G01N33/588 ,  Y10S977/774 ,  Y10S977/902 ,  Y10T436/108331

公开(公告)号：EP2531569A2

公开(公告)日：2012-12-12

申请号：EP11703788.7

申请日：2011-02-01

申请人： Ventana Medical Systems, Inc.

发明人： MAY, Eric ,  NAGY, Alexandra ,  KOSMEDER, Jerome

IPC分类号： C09K11/02 ,  G01N33/533 ,  G01N33/58

CPC分类号： C09K11/025 ,  B82Y15/00 ,  C09K11/883 ,  G01N33/533 ,  G01N33/588 ,  Y10S977/774 ,  Y10S977/902 ,  Y10T436/108331

摘要： Embodiments of a composition for stabilizing fluorescent signal of nanoparticles and methods for its use are disclosed. In some embodiments, the composition has a pH from 7 to 10 and includes borate, protein and/or protein hydrolysate, an amine, a preservative, and a nonionic surfactant. In particular embodiments, the amine is an
N -ethanol substituted amine, such as ethanolamine, diethanolamine, triethanolamine,
N -methyldiethanolamine, N,N-dimethylethanolamine, or a combination thereof. In some embodiments, a fluorescent particle solution, such as a quantum dot solution or quantum dot conjugate solution, is diluted in the composition and stored at 4°C. In certain embodiments, the fluorescence intensity of the diluted fluorescent particle remains substantially the same when stored at 4°C for at least one month or at least three months. In particular embodiments, a diluted quantum dot conjugate is used to detect a hybridized probe or a protein antigen.