公开(公告)号：EP1210330B1

公开(公告)日：2005-04-20

申请号：EP99938453.0

申请日：1999-08-10

申请人： Vernalis (Oxford) Ltd

发明人： HUNTER, Michael George, British Biotech Pharm. Ltd ,  BECKETT, Raymond Paul, British Biotech Pharm. Ltd ,  CLEMENTS, John Martin, British Biotech Pharm. Ltd ,  WHITTAKER, Mark, British Biotech Pharm. Ltd ,  DAVIES, Stephen John, British Biotech Pharm. Ltd ,  PRATT, Lisa Marie, British Biotech Pharm. Ltd ,  SPAVOLD, Zoe Marie, British Biotech Pharm. Ltd ,  LAUNCHBURY, Steven, British Biotech Pharm.Ltd

IPC分类号： C07D211/16 ,  C07D295/18 ,  A61K31/16 ,  C07D295/22 ,  C07C259/06 ,  C07D211/60 ,  C07D295/20 ,  C07D217/06 ,  C07D211/48 ,  C07C321/16 ,  C07C279/14 ,  A61K31/445 ,  A61K31/495 ,  A61K31/47 ,  A61P31/04 ,  C07D211/58

CPC分类号： C07D295/185 ,  C07C259/06 ,  C07C279/14 ,  C07C321/16 ,  C07D211/16 ,  C07D211/48 ,  C07D211/58 ,  C07D211/60 ,  C07D217/06 ,  C07D295/205 ,  C07D295/32

摘要： Selected compounds of formula (I) are antibacterial agents: formula (I) wherein R2 represents a substituted or unsubstituted C1-C6 alkyl, cycloalkyl (C1-C6 alkyl)- or aryl (C1-C6 alkyl)- group, and A represents a group of formula (IA), or (IB) wherein R4 represents the side chain of a natural or non-natural alpha amino acid, and R5 and R6 are each independently hydrogen or C1-C6 alkyl, heterocyclic or aryl (C1-C6 alkyl)-, R5 and R6 when taken together with the nitrogen atom to which they are attached from an optionally substituted saturated heterocyclic ring of 3 to 8 atoms which ring is optionally fused to a carbocyclic or second heterocyclic ring.