公开(公告)号：EP1881983A1

公开(公告)日：2008-01-30

申请号：EP06770824.8

申请日：2006-05-22

申请人： Vertex Pharmaceuticals, Inc.

发明人： WANNAMAKER, Marion, W. ,  LEDEBOER, Mark, W. ,  PIERCE, Albert, C. ,  WANG, Tiansheng ,  FARMER, Luc, J. ,  MARTINEZ-BOTELLA, Gabriel ,  BEMIS, Guy, W. ,  BETHIEL, Randy, S. ,  COME, Jon, H. ,  ARNOST, Michael, J. ,  SALITURO, Francesco, G. ,  WANG, Jian ,  MARHEFKA, Craig ,  STEWART, Michelle ,  GREEN, Jeremy

IPC分类号： C07D471/04 ,  C07D487/04 ,  A61K31/437 ,  A61P35/00

CPC分类号： C07D471/04 ,  C07D487/04

摘要： The present invention relates to compounds of formula (I) wherein Q, Z, R1 , R2 , and R3 are as described in claim 1 useful as inhibitors of protein kinases, particularly of JAK family and ROCK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

公开(公告)号：EP1881983B1

公开(公告)日：2012-01-11

申请号：EP06770824.8

申请日：2006-05-22

申请人： Vertex Pharmaceuticals, Inc.

发明人： WANNAMAKER, Marion, W. ,  LEDEBOER, Mark, W. ,  PIERCE, Albert, C. ,  WANG, Tiansheng ,  FARMER, Luc, J. ,  MARTINEZ-BOTELLA, Gabriel ,  BEMIS, Guy, W. ,  BETHIEL, Randy, S. ,  COME, Jon, H. ,  ARNOST, Michael, J. ,  SALITURO, Francesco, G. ,  WANG, Jian ,  MARHEFKA, Craig ,  STEWART, Michelle ,  GREEN, Jeremy

IPC分类号： C07D471/04 ,  C07D487/04 ,  A61K31/437 ,  A61P35/00

CPC分类号： C07D471/04 ,  C07D487/04

摘要： The present invention relates to compounds of formula (I) wherein Q, Z, R1 , R2 , and R3 are as described in claim 1 useful as inhibitors of protein kinases, particularly of JAK family and ROCK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.